B2M 靶点信息

B2M 分子靶点信息概述

  • 分子名：B2M, beta-2-microglobulin
  • 基因家族：C1-set domain containing

B2M 分子靶点综述

B2M，亦称β2-微球蛋白或CDABP0092，是MHC I类分子的组成成分，在所有有核细胞（不含红细胞）中均有表达。MHC I类分子的主要功能是将细胞内蛋白片段呈递给T细胞，携带外来蛋白的细胞将遭受免疫攻击。B2M（β2-微球蛋白）是一种低分子量蛋白质，研究证实其定位于有核细胞膜表面并与HL-A抗原结合。该蛋白以游离形式存在于多种体液中，同时作为组织相容性抗原的亚基与α3链并列分布于细胞表面。与α3链不同，β2链无跨膜结构域。其正上方为α1链，该链与α2链并列分布。若缺乏B2M（β2-微球蛋白），细胞表面仅能检测到极少量MHC I类（经典与非经典）分子。当MHC I类分子缺失时，参与获得性免疫的CD8 T细胞亚群将无法发育。

B2M 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human B2M 分子靶点信息

  • 分子名：B2M, beta-2-microglobulin
  • 别称：
    • AMYLD6
    • beta chain of MHC class I molecules
    • beta-2 microglobulin
    • beta-2-microglobin
    • IMD43
    • MHC1D4
  • 基因序列：NCBI_Gene: 567
  • 蛋白序列：UniProtKB: P61769

人 Human B2M 靶点分子功能（预测）

Enables protein homodimerization activity and structural molecule activity. Involved in several processes, including defense response to symbiont; negative regulation of cell differentiation; and regulation of receptor-mediated endocytosis. Located in Golgi apparatus; cytosol; and plasma membrane. Part of HFE-transferrin receptor complex and MHC class I peptide loading complex. Implicated in arthritis; immunodeficiency 43; and inflammatory bowel disease. Biomarker of several diseases, including artery disease (multiple); encephalomyelitis; measles; obesity; and type 2 diabetes mellitus.

小鼠 Mouse B2M 分子靶点信息

小鼠 Mouse B2m 靶点分子功能（预测）

Predicted to enable several functions, including MHC class II protein complex binding activity; peptide antigen binding activity; and protein homodimerization activity. Involved in learning or memory; negative regulation of cell differentiation; and sensory perception of smell. Acts upstream of or within several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cellular response to iron(III) ion; and multicellular organismal-level iron ion homeostasis. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study hemochromatosis. Human ortholog(s) of this gene implicated in arthritis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin).

大鼠 Rat B2m 分子靶点信息

  • 分子名：B2m, beta-2 microglobulin
  • 别称：
    • Beta-2-microglobulin
    • beta-2-microglobulin C-terminal fragment (55 AA)
  • 基因序列：NCBI_Gene: 24223
  • 蛋白序列：

大鼠 Rat B2m 靶点分子功能（预测）

Predicted to enable several functions, including MHC class II protein complex binding activity; peptide antigen binding activity; and protein homodimerization activity. Involved in response to cadmium ion and response to xenobiotic stimulus. Located in extracellular space. Biomarker of acute kidney failure; pyelonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in arthritis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin).

B2M 分子产品列表

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