文章目录[隐藏]
ADGRE1 分子靶点信息概述
- 分子名：ADGRE1, adhesion G protein-coupled receptor E1
- 基因家族：Adhesion G protein-coupled receptors, subfamily E
- 曾用名：TM7LN3; EMR1
- 全称：egf-like module containing, mucin-like, hormone receptor-like sequence 1; egf-like module containing, mucin-like, hormone receptor-like 1
ADGRE1 分子靶点综述
F4/80 是一个跨膜蛋白，虽然也会在枯否氏细胞和朗格汉斯细胞上表达，但仍可作为巨噬细胞的标志。骨髓细胞在体外受到巨噬细胞集落刺激因子刺激后，会上调 F4/80 抗原表达。诱导 CD8+ T 细胞介导的外周耐受也需要 F4/80 的参与。
ADGRE1, adhesion G protein-coupled receptor E1 分子靶点种属信息
人 Human ADGRE1 分子靶点信息
- 分子名：ADGRE1, adhesion G protein-coupled receptor E1
- 别称：
- egf-like module containing, mucin-like, hormone receptor-like 1
- egf-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-like module receptor 1
- EGF-like module-containing mucin-like hormone receptor-like 1
- EMR1
- EMR1 hormone receptor
- TM7LN3
- 基因序列：NCBI_Gene: 2015
- 蛋白序列：UniProtKB: Q14246
人 Human ADGRE1靶点分子功能（预测）
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane.
小鼠 Mouse Adgre1 分子靶点信息
- 分子名：Adgre1, adhesion G protein-coupled receptor E1
- 别称：
- DD7A5-7
- EGF-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-TM7
- Emr1
- F4/80
- glycoprotein f4/80 protein
- Gpf480
- Ly71
- lymphocyte antigen 71
- TM7LN3
- 基因序列：NCBI_Gene: 13733
- 蛋白序列：
小鼠 Mouse Adgre1 靶点分子功能（预测）
Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).
大鼠 Rat Adgre1 分子靶点信息
- 分子名：Adgre1, adhesion G protein-coupled receptor E1
- 别称：
- adhesion G protein-coupled receptor E2
- cell surface glycoprotein EMR1
- EGF-like module containing, mucin-like, hormone receptor-like 1
- EGF-like module containing, mucin-like, hormone receptor-like sequence 1
- EGF-like module receptor 1
- EGF-like module-containing mucin-like hormone receptor-like 1
- Emr1
- EMR1 hormone receptor
- 基因序列：NCBI_Gene: 316137
- 蛋白序列：UniProtKB: Q5Y4N8
大鼠 Rat Adgre1 靶点分子功能（预测）
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1).
