ACE2 靶点信息

ACE2 分子靶点信息概述

  • 分子名：ACE2, angiotensin converting enzyme 2
  • 别名：ACEH
  • 全称：peptidyl-dipeptidase A; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2

ACE2 分子靶点综述

血管紧张素转换酶2（ACE-2），也称为ACEH（ACE同源物），是ACE家族不可或缺的膜蛋白和锌金属蛋白酶。ACE2是肾素-血管紧张素系统中调节血压的关键酶。ACE-2裂解血管紧张素I和II作为羧肽酶。具体而言，ACE2分别从血管紧张素I切割末端九肽或从血管紧张素II切割末端七肽以产生血管紧张素。产生的肽可抵抗血管紧张素II的作用，并起血管扩张剂的作用。ACE-2已被证明是人类冠状病毒SARS-CoV和SARS-CoV-2的功能性受体。

ACE2, angiotensin converting enzyme 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ACE2 分子靶点信息

  • 分子名：ACE2, angiotensin converting enzyme 2
  • 别称：
    • ACE-related carboxypeptidase
    • ACEH
    • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
    • angiotensin I converting enzyme 2
    • angiotensin-converting enzyme 2
    • angiotensin-converting enzyme homolog
    • angiotensin-converting enzyme-related carboxypeptidase
    • DKFZp434A014
    • metalloprotease MPROT15
    • peptidyl-dipeptidase A
    • truncated angiotensin converting enzyme 2
  • 基因序列：NCBI_Gene: 59272
  • 蛋白序列：UniProtKB: Q9BYF1

人 Human ACE2靶点分子功能（预测）

Enables identical protein binding activity; peptidase activity; and virus receptor activity. Involved in several processes, including angiotensin-mediated drinking behavior; positive regulation of gap junction assembly; and regulation of transmembrane transport. Located in cell surface; extracellular space; and plasma membrane. Part of apical plasma membrane and brush border membrane. Implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Biomarker of congestive heart failure; hypertrophic cardiomyopathy; and pancreatic ductal carcinoma.

小鼠 Mouse Ace2 分子靶点信息

小鼠 Mouse Ace2 靶点分子功能（预测）

Predicted to enable identical protein binding activity; peptidase activity; and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Located in brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).

大鼠 Rat Ace2 分子靶点信息

大鼠 Rat Ace2 靶点分子功能（预测）

Enables carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Located in extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).

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