VEGFD 靶点信息

VEGFD 分子靶点信息概述

  • 分子名：VEGFD, vascular endothelial growth factor D
  • 基因家族：VEGF family
  • 别名：VEGF-D
  • 曾用名：FIGF
  • 全称：c-fos induced growth factor (vascular endothelial growth factor D)

VEGFD 分子靶点综述

血管内皮生长因子D(VEGF-D)，又名C-fos诱导的生长因子(FIGF)，是PDGF/VEGF家族中的一员，活跃在血管再生、淋巴管生成和内皮细胞生长中。该分泌蛋白经历一个复杂的蛋白水解成熟过程，形成可结合和活化VEGFR2、VEGFR3受体的多种加工形式。VEGF-D的结构和功能类似于VEGF-C。VEGF与多种类型的人类恶性肿瘤相关。在多种人类肿瘤的组织和患者的血清样本中发现VEGF-D是过表达的。另外，VEGF-D的表达与区域淋巴结转移发生率的升高有关。小鼠实验研究表明，产生VEGF-D蛋白的转基因肿瘤细胞可增强区域淋巴结转移。

VEGFD, vascular endothelial growth factor D 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human VEGFD 分子靶点信息

  • 分子名：VEGFD, vascular endothelial growth factor D
  • 别称：
    • c-fos induced growth factor
    • c-fos induced growth factor (vascular endothelial growth factor D)
    • c-fos-induced growth factor
    • FIGF
    • VEGF-D
  • 基因序列：NCBI_Gene: 2277
  • 蛋白序列：UniProtKB: O43915

人 Human VEGFD靶点分子功能（预测）

Enables chemoattractant activity and vascular endothelial growth factor receptor binding activity. Involved in induction of positive chemotaxis and positive regulation of mast cell chemotaxis. Predicted to be located in extracellular region and platelet alpha granule lumen. Predicted to be active in extracellular space. Biomarker of ovarian carcinoma and urinary bladder cancer.

小鼠 Mouse Vegfd 分子靶点信息

小鼠 Mouse Vegfd 靶点分子功能（预测）

Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; cerebellum; integumental system; limb; and skeleton. Orthologous to human FGF21 (fibroblast growth factor 21).

大鼠 Rat Vegfd 分子靶点信息

  • 分子名：Vegfd, vascular endothelial growth factor D
  • 别称：
    • c-fos induced growth factor
    • c-fos induced growth factor (vascular endothelial growth factor D)
    • c-fos-induced growth factor
    • Figf
    • Vegf-d
  • 基因序列：NCBI_Gene: 360457
  • 蛋白序列：

大鼠 Rat Vegfd 靶点分子功能（预测）

Enables vascular endothelial growth factor receptor binding activity. Involved in several processes, including positive regulation of interleukin-6 production; regulation of vascular endothelial growth factor receptor signaling pathway; and response to interleukin-1. Predicted to be located in extracellular space. Orthologous to human VEGFD (vascular endothelial growth factor D).

VEGFD 分子产品列表

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