PGF 靶点信息

PGF 分子靶点信息概述

  • 分子名：PGF, placental growth factor
  • 基因家族：VEGF family
  • 别名：PlGF-2; SHGC-10760; D12S1900; PIGF; PLGF; PlGF
  • 曾用名：PGFL
  • 全称：placental growth factor-like; placental growth factor, vascular endothelial growth factor-related protein; placenta growth factor

PGF 分子靶点综述

胎盘生长因子(PIGF)是血管内皮生长因子(VEGF)亚家族中的一员，是血管生成、特别是胚胎发育过程中的关键分子。妊娠期间，胎盘滋养层是 PIGF 的主要来源。许多其它组织，包括绒毛滋养细胞也能表达 PIGF。人类动脉粥样硬化损伤中的 PIGF 表达与斑块炎症和新生血管生长有关。在早发型和晚发型子痫前期，母体血清中的 sFlt-1 水平较高、PIGF 水平较低。

PGF, placental growth factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PGF 分子靶点信息

  • 分子名：PGF, placental growth factor
  • 别称：
    • D12S1900
    • PGFL
    • PIGF
    • placenta growth factor
    • placental growth factor-like
    • placental growth factor, vascular endothelial growth factor-related protein
    • PLGF
    • PlGF-2
    • SHGC-10760
  • 基因序列：NCBI_Gene: 5228
  • 蛋白序列：UniProtKB: P49763

人 Human PGF靶点分子功能（预测）

Enables growth factor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); epilepsy (multiple); limited scleroderma; and pancreatic endocrine carcinoma.

小鼠 Mouse Pgf 分子靶点信息

小鼠 Mouse Pgf 靶点分子功能（预测）

Predicted to enable identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor binding activity. Acts upstream of or within branching involved in ureteric bud morphogenesis and regulation of morphogenesis of a branching structure. Located in extracellular space. Is expressed in several structures, including brain; gut gland; musculature; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Orthologous to human PGF (placental growth factor).

大鼠 Rat Pgf 分子靶点信息

大鼠 Rat Pgf 靶点分子功能（预测）

Enables identical protein binding activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; and sprouting angiogenesis. Located in extracellular space. Used to study congestive heart failure and myocardial infarction. Biomarker of diabetic retinopathy; end stage renal disease; pre-eclampsia; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Orthologous to human PGF (placental growth factor).

PGF 分子产品列表

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