LTA 靶点信息

LTA 分子靶点信息概述

  • 分子名：LTA, lymphotoxin alpha
  • 基因家族：Tumor necrosis factor superfamily
  • 别名：TNFSF1; LT
  • 曾用名：TNFB
  • 全称：TNF superfamily member 1; lymphotoxin alpha (TNF superfamily, member 1)

LTA 分子靶点综述

肿瘤坏死因子β(TNF-β)，又称为淋巴毒素α，是由淋巴细胞分泌的细胞因子。TNF-β介导许多炎症、免疫刺激和抗病毒应答。在发育阶段，TNF-β还参与二级淋巴器官的形成，并在凋亡中发挥作用。在TNF-β敲除小鼠中，所有派伊尔氏淋巴集结和淋巴结都无法发育，这表明了TNF-β在免疫发育中的重要性。

LTA, lymphotoxin alpha 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LTA 分子靶点信息

  • 分子名：LTA, lymphotoxin alpha
  • 别称：
    • CDF
    • cholinergic differentiation factor
    • D factor
    • DIA
    • differentiation inhibitory activity
    • differentiation stimulating factor
    • differentiation-inducing factor
    • differentiation-stimulating factor
    • hepatocyte-stimulating factor III
    • HILDA
    • human interleukin in DA cells
    • leukemia inhibitory factor
    • LIF, interleukin 6 family cytokine
    • melanoma-derived LPL inhibitor
    • MLPLI
  • 基因序列：NCBI_Gene: 4049
  • 蛋白序列：UniProtKB: P01374

人 Human LTA靶点分子功能（预测）

Enables cytokine activity; growth factor activity; and leukemia inhibitory factor receptor binding activity. Involved in several processes, including leukemia inhibitory factor signaling pathway; positive regulation of protein modification process; and regulation of epithelial cell differentiation involved in kidney development. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of macrophage differentiation; and positive regulation of protein phosphorylation. Located in cytosol.

小鼠 Mouse Lta 分子靶点信息

小鼠 Mouse Lta 靶点分子功能（预测）

Predicted to enable tumor necrosis factor receptor binding activity. Acts upstream of or within several processes, including lymph node development; positive regulation of immune response; and positive regulation of interferon-gamma production. Predicted to be located in extracellular space. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha).

大鼠 Rat Lta 分子靶点信息

  • 分子名：Lta, lymphotoxin alpha
  • 别称：
    • LOC103690381
    • LT-alpha
    • lymphotoxin A
    • Lymphotoxin alpha (formerly tumor necrosis factor beta)
    • Lymphotoxin alpha (formerly tumor necrosis factor, beta)
    • lymphotoxin alpha (TNF superfamily, member 1)
    • lymphotoxin-alpha
    • lymphotoxin-alpha-like
    • TNF-beta
    • Tnfb
    • tumor necrosis factor beta
    • tumor necrosis factor ligand superfamily member 1
  • 基因序列：NCBI_Gene: 25008
  • 蛋白序列：UniProtKB: Q06332

大鼠 Rat Lta 靶点分子功能（预测）

Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of fibroblast proliferation; positive regulation of glial cell proliferation; and response to lipopolysaccharide. Located in extracellular space. Biomarker of cystitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha).

LTA 分子产品列表

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