LIF 靶点信息

LIF 分子靶点信息概述

  • 分子名：LIF, LIF interleukin 6 family cytokine
  • 基因家族：Receptor ligands; Interleukin 6 type cytokine family
  • 别名：CDF; DIA; HILDA
  • 全称：differentiation inhibitory activity; differentiation-inducing factor; hepatocyte-stimulating factor III; cholinergic differentiation factor; human interleukin in DA cells; leukemia inhibitory factor; LIF, interleukin 6 family cytokine

LIF 分子靶点综述

白血病抑制因子(LIF)是一种白细胞介素6家族细胞因子，通过抑制分化影响细胞生长。当LIF水平下降时，细胞就会分化。活化的T细胞、单核细胞、星形胶质细胞、成骨细胞、角质形成细胞、肥大细胞和成纤维细胞都可表达LIF。LIF因其能诱导髓系白血病细胞的终端分化，阻止白血病细胞的持续增长而得名。LIF的其它特性包括促进生长、促进不同类型的靶细胞分化、影响骨代谢、恶病质、神经发育、胚胎发育和炎症。LIF参与孕期子宫内膜蜕膜化和胚胎植入子宫内膜的过程。女性体内的LIF和其它细胞因子水平下降时，就容易怀孕，但是不明原因复发性流产的风险会增加。研究表明重组人LIF可能有助于改善女性不明原因不孕不育的着床率。另外，LIF通常用来添加到干细胞培养基中来减少自发分化。

LIF, LIF interleukin 6 family cytokine 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LIF 分子靶点信息

  • 分子名：LIF, LIF interleukin 6 family cytokine
  • 别称：
    • CDF
    • cholinergic differentiation factor
    • D factor
    • DIA
    • differentiation inhibitory activity
    • differentiation stimulating factor
    • differentiation-inducing factor
    • differentiation-stimulating factor
    • hepatocyte-stimulating factor III
    • HILDA
    • human interleukin in DA cells
    • leukemia inhibitory factor
    • LIF, interleukin 6 family cytokine
    • melanoma-derived LPL inhibitor
    • MLPLI
  • 基因序列：NCBI_Gene: 3976
  • 蛋白序列：UniProtKB: P15018

人 Human LIF靶点分子功能（预测）

Enables cytokine activity; growth factor activity; and leukemia inhibitory factor receptor binding activity. Involved in several processes, including leukemia inhibitory factor signaling pathway; positive regulation of protein modification process; and regulation of epithelial cell differentiation involved in kidney development. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of macrophage differentiation; and positive regulation of protein phosphorylation. Located in cytosol.

小鼠 Mouse Lif 分子靶点信息

小鼠 Mouse Lif 靶点分子功能（预测）

Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including animal organ development; generation of neurons; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; cranium; early conceptus; and female reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine).

大鼠 Rat Lif 分子靶点信息

  • 分子名：Lif, LIF, interleukin 6 family cytokine
  • 别称：
    • cholinergic neuronal differentiation factor
    • leukemia inhibitory factor
    • leukemia inhibitory factor (cholinergic differentiation factor)
  • 基因序列：NCBI_Gene: 60584
  • 蛋白序列：

大鼠 Rat Lif 靶点分子功能（预测）

Enables leukemia inhibitory factor receptor binding activity. Involved in several processes, including negative regulation of angiogenesis; positive regulation of corticotropin secretion; and transdifferentiation. Located in extracellular space. Biomarker of brain ischemia and congestive heart failure. Orthologous to human LIF (LIF interleukin 6 family cytokine).

LIF 分子产品列表

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