IL1RN 靶点信息

IL1RN 分子靶点信息概述

  • 分子名：IL1RN, interleukin 1 receptor antagonist
  • 基因家族：Interleukins; Interleukin receptors
  • 别名：IL1RA; ICIL-1RA; IL1F3; IRAP; IL-1RN; MGC10430
  • 全称：interleukin-1 receptor antagonist protein; intracellular interleukin-1 receptor antagonist

IL1RN 分子靶点综述

白细胞介素-1受体拮抗剂(IL-1ra，又称IL-1F3)是包括IL-1α和IL-1β的IL-1细胞因子家族的一员。IL-1ra通过与IL-1R1受体结合抑制白细胞介素-1的活性，并阻止其与信号传导的辅助受体IL-1RAP结合。小鼠白细胞介素-1受体拮抗剂(IL-1ra)是一种由多种细胞类型产生的22-25kda糖蛋白。已知分泌IL-1ra的细胞包括真皮成纤维细胞、血管平滑肌细胞、肠柱状上皮细胞、软骨细胞、巨噬细胞、未角化复层鳞状上皮细胞、肥大细胞、中性粒细胞和单核细胞、支持细胞和肝细胞。IL-1ra有两种I型跨膜糖蛋白受体:具有生物活性的80 kDa I型IL-1受体(IL-1 RI)和惰性的65 kDa II型IL-1受体(IL-1 RII)。IL-1ra可阻断IL-1的促炎作用，包括前列腺素E2和IL-6从内皮细胞的释放、发热、血小板增多、肝脏急性期蛋白的产生以及中性粒细胞的扩张和浸润。

IL1RN, interleukin 1 receptor antagonist 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL1RN 分子靶点信息

  • 分子名：IL1RN, interleukin 1 receptor antagonist
  • 别称：
    • DIRA
    • ICIL-1RA
    • IL-1ra
    • IL-1ra3
    • IL-1RN
    • IL1 inhibitor
    • IL1F3
    • IL1RA
    • IL1RN (IL1F3)
    • interleukin-1 receptor antagonist protein
    • intracellular IL-1 receptor antagonist type II
    • intracellular interleukin-1 receptor antagonist (icIL-1ra)
    • IRAP
    • MGC10430
    • MVCD4
    • type II interleukin-1 receptor antagonist
  • 基因序列：NCBI_Gene: 3557
  • 蛋白序列：UniProtKB: P18510

人 Human IL1RN靶点分子功能（预测）

Enables cytokine receptor binding activity. Involved in several processes, including acute-phase response; negative regulation of heterotypic cell-cell adhesion; and negative regulation of interleukin-1-mediated signaling pathway. Located in extracellular space. Implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); chronic kidney disease (multiple); glomerulonephritis (multiple); lung disease (multiple); and obesity (multiple).

小鼠 Mouse Il1rn 分子靶点信息

小鼠 Mouse Il1rn 靶点分子功能（预测）

Predicted to enable cytokine receptor binding activity. Acts upstream of or within insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist).

大鼠 Rat Il1rn 分子靶点信息

大鼠 Rat Il1rn 靶点分子功能（预测）

Enables interleukin-1 receptor binding activity. Involved in several processes, including cellular response to norepinephrine stimulus; chronic inflammatory response to antigenic stimulus; and fever generation. Located in extracellular space. Used to study adult respiratory distress syndrome; anti-basement membrane glomerulonephritis; hypertension; silicosis; and transient cerebral ischemia. Biomarker of encephalitis and pneumonia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist).

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