IL15 靶点信息

IL15 分子靶点信息概述

  • 分子名：IL15, interleukin 15
  • 基因家族：Interleukins
  • 别名：IL-15; MGC9721

IL15 分子靶点综述

白细胞介素15(IL-15)是一种促炎性蛋白，在中性粒细胞、树突状细胞和巨噬细胞的活化中起作用，对于NK细胞和CD8+T细胞的发育和生存是必不可少的。IL-15通过异三聚体受体信号激活Jak/Stat途径。虽然IL-15mRNA在许多细胞类型中表达，但是该分泌蛋白在生物样品中很少检测得到。最近的研究表明，IL-15滞留在胞内，只有当与其唯一的受体IL-15Rα形成复合物才能分泌到胞外。可溶性IL-15/IL-15R复合物由小鼠树突状细胞、成纤维细胞和巨噬细胞产生，它的结合活性比单独的IL-15提高10-100倍。

IL15, interleukin 15 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL15 分子靶点信息

人 Human IL15靶点分子功能（预测）

Predicted to enable cytokine activity. Involved in several processes, including cell surface receptor signaling pathway; macrophage differentiation; and positive regulation of macromolecule metabolic process. Located in cytosol and nuclear speck. Implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); brain infarction; lung disease (multiple); obesity; and viral infectious disease (multiple).

小鼠 Mouse Il15 分子靶点信息

小鼠 Mouse Il15 靶点分子功能（预测）

Enables cytokine activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T cell activation; lymph node development; and regulation of lymphocyte activation. Located in cytoplasm. Is expressed in several structures, including adrenal gland; genitourinary system; gut; immune system; and nervous system. Human ortholog(s) of this gene implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Orthologous to human IL15 (interleukin 15).

大鼠 Rat Il15 分子靶点信息

大鼠 Rat Il15 靶点分子功能（预测）

Predicted to enable cytokine activity. Involved in several processes, including cellular response to vitamin D; positive regulation of tyrosine phosphorylation of STAT protein; and skeletal muscle atrophy. Located in cell surface and extracellular space. Used to study pancreatitis. Biomarker of listeriosis and periodontal disease. Human ortholog(s) of this gene implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Orthologous to human IL15 (interleukin 15).

IL15 分子产品列表

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