文章目录[隐藏]
GZMB 分子靶点信息概述
- 分子名：GZMB, granzyme B
- 基因家族：Granule associated serine proteases of immune defence
- 别名：CCPI; CGL-1; CSP-B; CGL1; CTSGL1; HLP; SECT
- 曾用名：CTLA1; CSPB
- 全称：fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cell serine protease 1-3E; granzyme 2; cytotoxic T-lymphocyte-associated serine esterase 1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMB 分子靶点综述
颗粒酶B(GranzymeB)是一种丝氨酸蛋白酶，最常见于细胞毒性淋巴细胞(CTLs)和自然杀伤细胞(NK细胞)颗粒中。由这些细胞分泌的GranzymeB和穿孔蛋白一起作用介导靶细胞的凋亡。最近，人们发现许多非细胞毒性细胞从嗜碱性粒细胞、肥大细胞到平滑肌细胞也可产生GranzymeB。GranzymeB通过刺激细胞因子的释放参与诱导炎症，同样也参与细胞外基质重塑。升高的GranzymeB水平与许多自身免疫性疾病、一些皮肤病和1型糖尿病有关。
GZMB, granzyme B 分子靶点种属信息
人 Human GZMB 分子靶点信息
- 分子名：GZMB, granzyme B
- 别称：
- C11
- cathepsin G-like 1
- CCPI
- CGL-1
- CGL1
- CSP-B
- CSPB
- CTLA-1
- CTLA1
- CTSGL1
- cytotoxic serine protease B
- cytotoxic T-lymphocyte proteinase 2
- cytotoxic T-lymphocyte-associated serine esterase 1
- fragmentin 2
- fragmentin-2
- granzyme 2
- granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
- granzyme-2
- HLP
- human lymphocyte protein
- lymphocyte protease
- SECT
- T-cell serine protease 1-3E
- 基因序列：NCBI_Gene: 3002
- 蛋白序列：UniProtKB: P10144
人 Human GZMB靶点分子功能（预测）
Enables serine-type endopeptidase activity. Involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Located in cytolytic granule. Biomarker of COVID-19; bronchiolitis obliterans; and chronic obstructive pulmonary disease.
小鼠 Mouse Gzme 分子靶点信息
- 分子名：Gzme, granzyme E
- 别称：
- CCP3
- Ctla-6
- Ctla6
- cytotoxic T lymphocyte-associated protein 6
- MCSP-2
- 基因序列：NCBI_Gene: 14942
- 蛋白序列：
小鼠 Mouse Gzme 靶点分子功能（预测）
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Predicted to act upstream of or within cytolysis. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in extraembryonic component; placenta; spongiotrophoblast; and trophoblast giant cell. Orthologous to human GZMB (granzyme B).
大鼠 Rat Gzmb 分子靶点信息
- 分子名：Gzmb, granzyme B
- 别称：
- fragmentin
- GLP I
- GLP III
- GLP-1
- granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
- granzyme-like protein 1
- granzyme-like protein I
- LOW QUALITY PROTEIN: granzyme-like protein 1
- MGC156565
- natural killer cell protease 1
- RNKP-1
- 基因序列：NCBI_Gene: 171528
- 蛋白序列：
大鼠 Rat Gzmb 靶点分子功能（预测）
Enables serine-type endopeptidase activity. Involved in positive regulation of necroptotic process. Located in early endosome. Orthologous to human GZMB (granzyme B).
