EPO 靶点信息

EPO 分子靶点信息概述

  • 分子名：EPO, erythropoietin
  • 基因家族：Receptor ligands
  • 别名：EP

EPO 分子靶点综述

促红细胞生成素(EPO)是一种34-39kda的分泌糖蛋白，属于Ⅰ型细胞因子超家族成员。EPO主要由肾脏(间质性肾小管周围成纤维细胞)和肝脏(肝细胞和Ito细胞)中的细胞产生，缺氧可上调EPO的生成。促红细胞生成素是调节红细胞增殖和分化，维持循环红细胞量的生理水平的主要激素。小鼠促红细胞生成素与大鼠促红细胞生成素的氨基酸序列同源性为94%，与人促红细胞生成素的氨基酸序列同源性为80%。EPO除了在促红细胞生成中的作用外，还作用于各种非造血细胞，发挥其作为一种生存和增殖因子的作用。EPO可以刺激成肌细胞增殖，同时抑制其分化，从而导致祖细胞群的扩大。EPO是一种组织保护因子，可保护神经、心血管和肾组织免受缺血性和毒性损伤。

EPO, erythropoietin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human EPO 分子靶点信息

人 Human EPO靶点分子功能（预测）

Enables cytokine activity and erythropoietin receptor binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of ion transport; and regulation of transcription, DNA-templated. Located in cell surface and extracellular space. Implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Biomarker of amyotrophic lateral sclerosis; anemia; breast cancer; eye disease (multiple); and glucose metabolism disease (multiple).

小鼠 Mouse Epo 分子靶点信息

小鼠 Mouse Epo 靶点分子功能（预测）

Enables protein kinase activator activity. Involved in negative regulation of apoptotic process; peptidyl-serine phosphorylation; and positive regulation of protein kinase activity. Acts upstream of or within several processes, including embryo implantation; erythrocyte differentiation; and hemoglobin biosynthetic process. Located in extracellular space. Is expressed in several structures, including egg cylinder; embryo mesenchyme; embryo mesoderm; nervous system; and placenta. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin).

大鼠 Rat Epo 分子靶点信息

大鼠 Rat Epo 靶点分子功能（预测）

Predicted to enable cytokine activity; erythropoietin receptor binding activity; and protein kinase activator activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of activated T cell proliferation; and response to dexamethasone. Located in cell body and extracellular space. Used to study retinal detachment and visual epilepsy. Biomarker of cholangiocarcinoma; eye disease (multiple); transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin).

EPO 分子产品列表

EPO 分子靶点最新资讯