BTC 靶点信息

BTC 分子靶点信息概述

  • 分子名：BTC, betacellulin

BTC 分子靶点综述

Betacellulin，也称为BTC蛋白，在人类中由4号染色体上4q13.3区的BTC基因编码。该基因编码的蛋白质是生长因子EGF家族的一员。它主要作为一个跨膜前体被合成，通过蛋白水解作用加工成成熟的分子。该蛋白是EGF受体的配体，与EGFR、ERBB4和其他EGF受体家族成员结合。同时它也是视网膜色素上皮细胞和血管平滑肌细胞的有效的有丝分裂原。 数据表明，BTC通过内皮细胞中EGF受体的激活、有丝分裂原活化的蛋白激酶和磷脂酰肌醇3'激酶/蛋白激酶可有效促进血管生成。

BTC, betacellulin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human BTC 分子靶点信息

人 Human BTC靶点分子功能（预测）

Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of epidermal growth factor-activated receptor activity; and positive regulation of mitotic nuclear division. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in clathrin-coated endocytic vesicle membrane and extracellular region. Predicted to be active in extracellular space. Implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Biomarker of insulinoma.

小鼠 Mouse Btc 分子靶点信息

小鼠 Mouse Btc 靶点分子功能（预测）

Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Acts upstream of or within negative regulation of apoptotic process and positive regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in lung; reproductive system; and skin. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human BTC (betacellulin).

大鼠 Rat Btc 分子靶点信息

大鼠 Rat Btc 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including positive regulation of fibroblast proliferation; positive regulation of mitotic nuclear division; and positive regulation of urine volume. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Biomarker of otitis media. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human BTC (betacellulin).

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