AGT 靶点信息

AGT 分子靶点信息概述

  • 分子名：AGT, angiotensinogen
  • 基因家族：Serpin peptidase inhibitors; Neuropeptides
  • 曾用名：SERPINA8
  • 全称：alpha-1 antiproteinase, antitrypsin; serpin peptidase inhibitor, clade A, member 8

AGT 分子靶点综述

血管紧张素原(AGT)，又称为SerpinA8，是丝氨酸蛋白酶抑制剂家族的一员。AGT是一个α-2-球蛋白，由肝脏组成性产生并释放到血液循环中。AGT是肾素-血管紧张素系统的一个必不可少的组分，是一个有效的血压调节剂。AGT可裂解成3条链：血管紧张素-1、血管紧张素-2和血管紧张素-3。AGT的缺失与原发性高血压及肾小管发育不全相关。一些丝氨酸蛋白酶抑制剂(抗凝血酶、maspin、色素上皮衍生因子和kallistatin)最近已被证明具有抗血管生成活性，表明内皮细胞增殖和迁移的共同机制。AGT和它的肾素裂解产物，在体外和体内可观察到的血浆浓度范围内，也是血管生成抑制剂。

AGT, angiotensinogen 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human AGT 分子靶点信息

  • 分子名：AGT, angiotensinogen
  • 别称：
    • alpha-1 antiproteinase, antitrypsin
    • angiotensin I
    • angiotensin II
    • angiotensinogen (serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 8)
    • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
    • ANHU
    • fetal-liver predominant transporter 1
    • FLJ92595
    • FLJ97926
    • hFLT1
    • pre-angiotensinogen
    • serine (or cysteine) proteinase inhibitor
    • serpin A8
    • serpin peptidase inhibitor, clade A, member 8
    • SERPINA8
  • 基因序列：NCBI_Gene: 183
  • 蛋白序列：UniProtKB: P01019

人 Human AGT靶点分子功能（预测）

Enables angiotensin receptor binding activity; receptor ligand activity; and sodium channel regulator activity. Involved in several processes, including positive regulation of peptidyl-tyrosine phosphorylation; regulation of gene expression; and regulation of signal transduction. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Biomarker of several diseases, including alcoholic hepatitis; chronic myeloid leukemia; intermediate coronary syndrome; systemic scleroderma (multiple); and type 2 diabetes mellitus.

小鼠 Mouse Agt 分子靶点信息

小鼠 Mouse Agt 靶点分子功能（预测）

Enables type 1 angiotensin receptor binding activity and type 2 angiotensin receptor binding activity. Involved in positive regulation of cytokine production. Acts upstream of or within several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).

大鼠 Rat Agt 分子靶点信息

  • 分子名：Agt, angiotensinogen
  • 别称：
    • Ang
    • AngII
    • angiotensin II
    • angiotensinogen (PAT)
    • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
    • ANRT
    • MGC105326
    • PAT
    • serpin A8
  • 基因序列：NCBI_Gene: 24179
  • 蛋白序列：UniProtKB: P01015

大鼠 Rat Agt 靶点分子功能（预测）

Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of ion transport; and regulation of secretion. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).

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