VCAM1 靶点信息

VCAM1 分子靶点信息概述

  • 分子名：VCAM1, vascular cell adhesion molecule 1
  • 基因家族：CD molecules; Receptor ligands; C2-set domain containing; I-set domain containing; Ig-like cell adhesion molecule family
  • 别名：CD106

VCAM1 分子靶点综述

血管细胞粘附分子1(VCAM-1)也称为CD106，是100-110kDaI型跨膜蛋白，通常具有7个C2型免疫球蛋白结构域，作为细胞黏附分子发挥功能。VCAM-1蛋白介导淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞等黏附于血管内皮。VCAM-1是整合素β1亚家族VLA-4(极迟抗原-4或α4β1)和整合素α4β7的内皮配体。在其他类型细胞上也观察到VCAM-1的表达。它也能与EZR和膜突蛋白作用。VCAM-1的其它功能包括通过细胞-细胞接触调控破骨细胞生成、血氧不足时诱导镰状细胞黏附于血管内皮细胞。它还在白细胞-内皮细胞信号传导中发挥作用。监测血清中的sVCAM-1表达水平可为多种病理状态提供更详细的视角，如动脉粥样硬化和类风湿性关节炎。

VCAM1, vascular cell adhesion molecule 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human VCAM1 分子靶点信息

  • 分子名：VCAM1, vascular cell adhesion molecule 1
  • 别称：
    • CD106
    • CD106 antigen
    • DKFZp779G2333
    • INCAM-100
    • MGC99561
    • vascular cell adhesion protein 1
  • 基因序列：NCBI_Gene: 7412
  • 蛋白序列：UniProtKB: P19320

人 Human VCAM1靶点分子功能（预测）

Enables integrin binding activity and primary amine oxidase activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cell-cell adhesion in response to extracellular stimulus; and cellular response to amyloid-beta. Located in several cellular components, including early endosome; external side of plasma membrane; and podosome. Part of alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); essential thrombocythemia; glomerulonephritis (multiple); and interstitial cystitis.

小鼠 Mouse Vcam1 分子靶点信息

小鼠 Mouse Vcam1 靶点分子功能（预测）

Predicted to enable integrin binding activity and primary amine oxidase activity. Acts upstream of or within several processes, including cellular response to glucose stimulus; chorio-allantoic fusion; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in apical plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; extraembryonic component; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human VCAM1 (vascular cell adhesion molecule 1).

大鼠 Rat Vcam1 分子靶点信息

大鼠 Rat Vcam1 靶点分子功能（预测）

Enables integrin binding activity. Involved in several processes, including cellular response to tumor necrosis factor; nervous system development; and response to lipopolysaccharide. Located in cell surface; extracellular space; and sarcolemma. Used to study carotid stenosis and hypertension. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; colitis; periodontitis; and thromboangiitis obliterans. Orthologous to human VCAM1 (vascular cell adhesion molecule 1).

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