TNFRSF9 靶点信息

TNFRSF9 分子靶点信息概述

  • 分子名：TNFRSF9, TNF receptor superfamily member 9
  • 基因家族：CD molecules; Tumor necrosis factor receptor superfamily
  • 别名：CD137; 4-1BB
  • 曾用名：ILA
  • 全称：tumor necrosis factor receptor superfamily, member 9

TNFRSF9 分子靶点综述

4-1BB，也称为TNFRSF9或CD137，是肿瘤坏死因子超家族的受体。人4-1BB基因编码由255个氨基酸组成的I型跨膜蛋白，包含17个氨基酸的N端信号肽、169个氨基酸的胞外区、27个氨基酸的跨膜区和42个氨基酸的胞外区。重组人可溶性4-1BB是一个167氨基酸的多肽(17.7kDa)，包括富含胱氨酸TNFR样的4-1BB胞外区。4-1BB主要表达于各种T细胞的表面，在B细胞、单核细胞和多种转化细胞系中也有表达。该蛋白有助于克隆增殖、存活和T细胞发育。它也能诱导外周单核细胞的增殖，增强由TCR/CD3触发活化而诱导的T细胞凋亡，同时调节CD28共刺激促进Th1细胞应答。该蛋白的表达是通过淋巴细胞活化诱导。TRAF转接蛋白可与该蛋白结合，并转导激活NF-κB的信号。它还参与高脂肪食源性代谢综合症中炎症的发展。

TNFRSF9, TNF receptor superfamily member 9 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFRSF9 分子靶点信息

  • 分子名：TNFRSF9, TNF receptor superfamily member 9
  • 别称：
    • 4-1BB
    • 4-1BB ligand receptor
    • CD137
    • CD137 antigen
    • CDw137
    • FLJ43501
    • homolog of mouse 4-1BB
    • ILA
    • induced by lymphocyte activation (ILA)
    • interleukin-activated receptor, homolog of mouse Ly63
    • MGC2172
    • receptor protein 4-1BB
    • T cell antigen ILA
    • T-cell antigen 4-1BB homolog
    • T-cell antigen ILA
    • tumor necrosis factor receptor superfamily member 9
    • tumor necrosis factor receptor superfamily, member 9
  • 基因序列：NCBI_Gene: 3604
  • 蛋白序列：UniProtKB: Q07011

人 Human TNFRSF9靶点分子功能（预测）

Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space. Predicted to be active in external side of plasma membrane.

小鼠 Mouse Tnfrsf9 分子靶点信息

小鼠 Mouse Tnfrsf9 靶点分子功能（预测）

Enables cytokine binding activity; identical protein binding activity; and signaling receptor activity. Acts upstream of or within negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; and regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Is expressed in renal vasculature. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9).

大鼠 Rat Tnfrsf9 分子靶点信息

  • 分子名：Tnfrsf9, TNF receptor superfamily member 9
  • 别称：
    • 4-1BB
    • LOC500590
    • MGC114552
    • similar to T-cell antigen 4-1BB precursor - mouse
    • tumor necrosis factor receptor superfamily member 9
    • tumor necrosis factor receptor superfamily, member 9
  • 基因序列：NCBI_Gene: 500590
  • 蛋白序列：UniProtKB: Q4V895

大鼠 Rat Tnfrsf9 靶点分子功能（预测）

Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9).

TNFRSF9 分子产品列表

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