CXCL12 靶点信息

CXCL12 分子靶点信息概述

  • 分子名：CXCL12, C-X-C motif chemokine ligand 12
  • 基因家族：Chemokine ligands
  • 别名：SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1
  • 曾用名：SDF1A; SDF1B; SDF1
  • 全称：stromal cell-derived factor 1; chemokine (C-X-C motif) ligand 12

CXCL12 分子靶点综述

趋化因子CXC配体12(CXCL12)也称为基质细胞衍生因子1(SDF-1)，是一种可活化白细胞的趋化因子蛋白，通常由促炎性刺激剂诱导产生，如LPS、TNF或IL-1。CXCL12对淋巴细胞具有强烈的趋化作用。在胚胎发生期，它可促使造血细胞从胎肝向骨髓迁移和大血管的形成。在成年人中，CXCL12在血管生成中具有重要作用，它通过CXCR4依赖的机制招募骨髓中的内皮祖细胞(EPCs)。CXCL12对肿瘤转移也有作用，表达CXCR4受体的癌细胞可被吸引至靶组织。然而在乳腺癌中，CXCL12表达升高则提示远端转移的风险降低。

CXCL12, C-X-C motif chemokine ligand 12 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CXCL12 分子靶点信息

  • 分子名：CXCL12, C-X-C motif chemokine ligand 12
  • 别称：
    • chemokine (C-X-C motif) ligand 12
    • intercrine reduced in hepatomas
    • IRH
    • PBSF
    • pre-B cell growth-stimulating factor
    • SCYB12
    • SDF-1a
    • SDF-1b
    • SDF1
    • SDF1A
    • SDF1B
    • stromal cell-derived factor 1
    • TLSF
    • TLSF-a
    • TLSF-b
    • TPAR1
  • 基因序列：NCBI_Gene: 6387
  • 蛋白序列：UniProtKB: P48061

人 Human CXCL12靶点分子功能（预测）

Enables CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including integrin activation; negative regulation of apoptotic process; and regulation of leukocyte migration. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in extracellular exosome. Part of collagen-containing extracellular matrix. Implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Biomarker of diabetic retinopathy; insulinoma; periodontitis; and type 2 diabetes mellitus.

小鼠 Mouse Cxcl12 分子靶点信息

  • 分子名：Cxcl12, chemokine (C-X-C motif) ligand 12
  • 别称：
    • AI174028
    • expressed sequence AI174028
    • PBSF
    • PBSF/SDF-1
    • Scyb12
    • SDF-1
    • Sdf1
    • Sdf1a
    • Sdf1b
    • stromal cell derived factor 1
    • stromal cell derived factor 1A
    • stromal cell derived factor 1B
    • TLSF-a
    • TLSF-b
    • TPAR1
  • 基因序列：NCBI_Gene: 20315
  • 蛋白序列：

小鼠 Mouse Cxcl12 靶点分子功能（预测）

Enables chemokine activity. Involved in dopaminergic neuron differentiation. Acts upstream of or within several processes, including gamete generation; nervous system development; and positive regulation of intracellular signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).

大鼠 Rat Cxcl12 分子靶点信息

  • 分子名：Cxcl12, C-X-C motif chemokine ligand 12
  • 别称：
    • chemokine (C-X-C motif) ligand 12
    • chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
    • SDF-1 gamma
    • Sdf1
    • Stromal cell-derived factor 1
    • stromal cell-derived factor-1 gamma
  • 基因序列：NCBI_Gene: 24772
  • 蛋白序列：

大鼠 Rat Cxcl12 靶点分子功能（预测）

Predicted to enable CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of ion transport. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study myocardial infarction. Biomarker of anti-basement membrane glomerulonephritis; brain ischemia; myocardial infarction; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).

CXCL12 分子产品列表

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