P4HB 靶点信息

P4HB 分子靶点信息概述

  • 分子名：P4HB, prolyl 4-hydroxylase subunit beta
  • 基因家族：Protein disulfide isomerases
  • 别名：PDIA1; PROHB; DSI; GIT; PDI; PO4HB; P4Hbeta
  • 曾用名：PO4DB; ERBA2L
  • 全称：protein disulfide isomerase-associated 1; protein disulfide isomerase family A, member 1; collagen prolyl 4-hydroxylase beta; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55); procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1); procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide; prolyl 4-hydroxylase, beta polypeptide

P4HB 分子靶点综述

蛋白质二硫键异构酶，又称脯氨酸4-羟化酶β亚基(P4HB)、细胞甲状腺激素结合蛋白(p55)和谷胱甘肽-胰岛素转氢酶，是一种外周膜蛋白，属于蛋白二硫键异构酶家族。它包含两个硫氧还蛋白结构域，催化二硫键的形成、断裂和重排。P4HB定位于淋巴细胞表面CD4富集区附近。在黑素小体组分中，P4HB可降低并激活HIV-1 gp120表面蛋白的融合特性，从而使HIV-1进入细胞。P4HB作为一种伴侣，抑制错误折叠蛋白的聚集。P4HB可能与其它分子伴侣参与了激素生物合成中TG前体的结构修饰。

P4HB, prolyl 4-hydroxylase subunit beta 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human P4HB 分子靶点信息

  • 分子名：P4HB, prolyl 4-hydroxylase subunit beta
  • 别称：
    • cellular thyroid hormone-binding protein
    • CLCRP1
    • collagen prolyl 4-hydroxylase beta
    • DSI
    • ERBA2L
    • GIT
    • glutathione-insulin transhydrogenase
    • P4Hbeta
    • p55
    • PDI
    • PDIA1
    • PHDB
    • PO4DB
    • PO4HB
    • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
    • PROHB
    • prolyl 4-hydroxylase, beta polypeptide
    • protein disulfide isomerase family A, member 1
    • protein disulfide isomerase-associated 1
    • protein disulfide isomerase/oxidoreductase
    • protein disulfide-isomerase
    • protocollagen hydroxylase
    • testicular secretory protein Li 32
    • thyroid hormone-binding protein p55
    • v-erb-a avian erythroblastic leukemia viral oncogene homolog 2-like
  • 基因序列：NCBI_Gene: 5034
  • 蛋白序列：UniProtKB: P07237

人 Human P4HB靶点分子功能（预测）

Enables several functions, including oxidoreductase activity, acting on a sulfur group of donors; protein disulfide isomerase activity; and protein heterodimerization activity. Contributes to procollagen-proline 4-dioxygenase activity. Involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein folding in endoplasmic reticulum. Acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; and lamellipodium. Part of procollagen-proline 4-dioxygenase complex. Implicated in Cole-Carpenter syndrome.

小鼠 Mouse P4hb 分子靶点信息

小鼠 Mouse P4hb 靶点分子功能（预测）

Enables integrin binding activity. Acts upstream of or within cellular response to interleukin-7. Located in endoplasmic reticulum and external side of plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta).

大鼠 Rat P4hb 分子靶点信息

  • 分子名：P4hb, prolyl 4-hydroxylase subunit beta
  • 别称：
    • cellular thyroid hormone-binding protein
    • PDI
    • PDIR
    • prolyl 4-hydroxylase, beta polypeptide
    • protein disulfide isomerase
    • protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide)
    • protein disulfide-isomerase
  • 基因序列：NCBI_Gene: 25506
  • 蛋白序列：UniProtKB: P04785

大鼠 Rat P4hb 靶点分子功能（预测）

Enables enzyme binding activity and protein disulfide isomerase activity. Predicted to be involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein folding in endoplasmic reticulum. Predicted to act upstream of or within cellular response to interleukin-7 and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum-Golgi intermediate compartment; and lamellipodium. Predicted to be part of endoplasmic reticulum chaperone complex and procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum and external side of plasma membrane. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta).

P4HB 分子产品列表

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