RBP4 靶点信息

RBP4 分子靶点信息概述

  • 分子名：RBP4, retinol binding protein 4
  • 基因家族：Lipocalins
  • 全称：retinol-binding protein 4, plasma

RBP4 分子靶点综述

视黄醇结合蛋白4(RBP4)属于载脂蛋白家族，是血液中视黄醇(维生素A醇)特异性的载体。它可将视黄醇从肝脏运输至外周组织。最近，RBP4被认为是一种脂肪因子，在AG4KO小鼠中有助于对胰岛素耐受。它由脂肪细胞分泌，当血糖浓度下降时，可对其它细胞传递信号。RBP4基因突变与常染色体显性小眼畸形、无眼和眼组织残缺有关。

RBP4, retinol binding protein 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human RBP4 分子靶点信息

  • 分子名：RBP4, retinol binding protein 4
  • 别称：
    • MCOPCB10
    • plasma retinol-binding protein
    • PRBP
    • RBP
    • RDCCAS
    • retinol binding protein 4, plasma
    • retinol-binding protein 4
    • retinol-binding protein 4, interstitial
  • 基因序列：NCBI_Gene: 5950
  • 蛋白序列：UniProtKB: P02753

人 Human RBP4靶点分子功能（预测）

Enables retinol binding activity. Involved in several processes, including gluconeogenesis; positive regulation of insulin secretion; and retinol metabolic process. Located in extracellular space. Implicated in type 2 diabetes mellitus. Biomarker of type 2 diabetes mellitus.

小鼠 Mouse Rbp4 分子靶点信息

小鼠 Mouse Rbp4 靶点分子功能（预测）

Enables retinol binding activity. Involved in several processes, including animal organ development; gluconeogenesis; and negative regulation of cardiac muscle cell proliferation. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4).

大鼠 Rat Rbp4 分子靶点信息

大鼠 Rat Rbp4 靶点分子功能（预测）

Enables retinol binding activity. Involved in response to ethanol and retinol transport. Located in extracellular space. Part of protein-containing complex. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4).

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