KMT2A 靶点信息

KMT2A 分子靶点信息概述

  • 分子名：KMT2A, lysine methyltransferase 2A
  • 基因家族：PHD finger proteins; Zinc fingers CXXC-type; Lysine methyltransferases; Bromodomain containing; SET domain containing
  • 别名：TRX1; HRX; ALL-1; HTRX1; CXXC7; MLL1A; MLL1; ALL1; HTRX
  • 曾用名：MLL
  • 全称：Histone-lysine N-methyltransferase 2A; myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); lysine (K)-specific methyltransferase 2A; Trithorax-like protein; CXXC-type zinc finger protein 7; Acute lymphocytic 1

KMT2A 分子靶点综述

硫氧还蛋白(Trxs)是一群广泛存在于所有活细胞中的小分子蛋白，是细胞氧化还原平衡的关键调节者。哺乳动物的Trx家族有三个成员：Trx-1、Trx-2和TrxL。Trx-1是唯一一个存在于细胞外的硫氧还蛋白，由淋巴细胞、肝细胞、成纤维细胞和多种肿瘤细胞分泌产生。血浆中Trx-1的浓度可达到6 nM。它主要存在于细胞的细胞质中，少量存在于细胞核以及与细胞外表面相关的地方。在各种应激条件下如缺氧、过氧化氢浓度升高、光化学氧化应激、病毒和细菌感染，Trx-1的表达增加。Trx-1的生物学功能包括生长因子活性、抗氧化性能、提供还原当量的辅因子和转录调控。类风湿性关节炎患者的滑膜组织在氧化应激条件下，其Trx-1水平增加。血浆中Trx-1水平与疾病的严重程度有关，表明Trx-1可作为病理条件的生物标志物。

KMT2A, lysine methyltransferase 2A 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human KMT2A 分子靶点信息

  • 分子名：KMT2A, lysine methyltransferase 2A
  • 别称：
    • ALL-1
    • CDK6/MLL fusion protein
    • CXXC-type zinc finger protein 7
    • CXXC7
    • FLJ11783
    • histone-lysine N-methyltransferase 2A
    • histone-lysine N-methyltransferase MLL
    • HRX
    • HTRX1
    • hypothetical protein FLJ11783
    • lysine (K)-specific methyltransferase 2A
    • lysine N-methyltransferase 2A
    • mixed lineage leukemia 1
    • MLL
    • MLL-AF4 der(11) fusion protein
    • MLL-AF9
    • MLL/GAS7
    • MLL/GAS7 fusion protein
    • MLL/GMPS fusion protein
    • MLL1
    • MLL1A
    • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    • myeloid/lymphoid or mixed-lineage leukemia protein 1
    • TET1-MLL
    • trithorax-like protein
    • TRX1
    • WDSTS
    • zinc finger protein HRX
  • 基因序列：NCBI_Gene: 4297
  • 蛋白序列：UniProtKB: Q03164

人 Human KMT2A靶点分子功能（预测）

Enables several functions, including lysine-acetylated histone binding activity; protein homodimerization activity; and protein methyltransferase activity. Involved in several processes, including histone modification; positive regulation of transporter activity; and regulation of nucleobase-containing compound metabolic process. Located in cytosol and nucleoplasm. Part of MLL1 complex. Implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Biomarker of prostate cancer.

小鼠 Mouse Kmt2a 分子靶点信息

小鼠 Mouse Kmt2a 靶点分子功能（预测）

Enables DNA binding activity; chromatin binding activity; and histone methyltransferase activity (H3-K4 specific). Involved in several processes, including definitive hemopoiesis; regulation of gene expression; and regulation of histone modification. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Used to study acute lymphoblastic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A).

大鼠 Rat Kmt2a 分子靶点信息

  • 分子名：Kmt2a, lysine methyltransferase 2A
  • 别称：
    • histone-lysine N-methyltransferase 2A
    • histone-lysine N-methyltransferase MLL
    • lysine (K)-specific methyltransferase 2A
    • Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or trithorax Drosophila gene)
    • Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
    • Mll
    • Mll_mapped
    • Mll1
    • myeloid/lymphoid or mixed-lineage leukemia
    • myeloid/lymphoid or mixed-lineage leukemia (mapped)
    • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    • myeloid/lymphoid or mixed-lineage leukemia 1
  • 基因序列：NCBI_Gene: 315606
  • 蛋白序列：UniProtKB: F1M0L3

大鼠 Rat Kmt2a 靶点分子功能（预测）

Predicted to enable protein C-terminus binding activity. Involved in several processes, including DNA metabolic process; animal organ regeneration; and cellular response to heat. Located in nucleus. Used to study high grade glioma; leiomyoma; and prostate carcinoma. Biomarker of colon cancer; kidney disease; mucositis; type 2 diabetes mellitus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67).

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