GH1 靶点信息

GH1 分子靶点信息概述

  • 分子名：GH1, growth hormone 1
  • 基因家族：Growth hormone family
  • 别名：GH-N; GHN; GH; hGH-N
  • 全称：pituitary growth hormone; somatotropin

GH1 分子靶点综述

在人和其它动物中，生长激素(GH)可刺激生长、细胞繁殖和细胞再生。因此它对人体发育很重要。生长激素是一种应激激素，可提高葡萄糖和游离脂肪酸的浓度。它还能促进IGF-1的产生。生长激素过剩最常见的疾病是垂体瘤。生长激素缺失产生的影响因年龄而异。对于小孩，生长停滞和身材矮小是生长激素缺失的主要表现，通常是由于遗传因素和先天畸形。它也能导致性成熟推迟。在成年人中，生长激素缺失是很少见的，最常见的原因是脑垂体瘤，其它原因包括儿童时期生长激素缺失的延续、其它的结构损伤或创伤以及极其罕见的特发性生长激素缺乏症(GHD)。

GH1, growth hormone 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human GH1 分子靶点信息

  • 分子名：GH1, growth hormone 1
  • 别称：
    • GH
    • GH-N
    • GHB5
    • GHN
    • growth hormone B5
    • hGH-N
    • IGHD1A
    • IGHD1B
    • IGHD2
    • pituitary growth hormone
    • somatotropin
  • 基因序列：NCBI_Gene: 2688
  • 蛋白序列：UniProtKB: P01241

人 Human GH1靶点分子功能（预测）

Enables growth factor activity; growth hormone receptor binding activity; and prolactin receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and positive regulation of signal transduction. Acts upstream of or within positive regulation of glucose transmembrane transport. Located in extracellular space. Part of growth hormone receptor complex. Colocalizes with collagen-containing extracellular matrix. Implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Biomarker of diabetes insipidus; diabetes mellitus (multiple); osteoarthritis; and severe acute respiratory syndrome.

小鼠 Mouse Gh 分子靶点信息

小鼠 Mouse Gh 靶点分子功能（预测）

Enables growth hormone receptor binding activity. Acts upstream of or within cellular response to insulin stimulus; regulation of growth; and response to food. Located in several cellular components, including extracellular space; secretory granule; and trans-Golgi network. Is expressed in brain; early conceptus; gut; hemolymphoid system; and male reproductive system. Used to study isolated growth hormone deficiency type II. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1).

大鼠 Rat Gh1 分子靶点信息

大鼠 Rat Gh1 靶点分子功能（预测）

Enables hormone activity. Involved in several processes, including cellular response to alkaline pH; cellular response to thyroid hormone stimulus; and generation of neurons. Located in several cellular components, including collagen-containing extracellular matrix; mitochondrion; and secretory granule. Used to study isolated growth hormone deficiency and type 1 diabetes mellitus. Biomarker of congenital hypothyroidism; osteoporosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1).

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