EPOR 靶点信息

EPOR 分子靶点信息概述

  • 分子名：EPOR, erythropoietin receptor
  • 基因家族：Fibronectin type III domain containing

EPOR 分子靶点综述

红细胞生成素受体 (EPOR) 在人类中由EPOR基因编码。它是一个分子量为59 kDa的多肽，是细胞因子受体家族中的一员。EPOR的胞质域包含许多Janus激酶2磷酸化的酪氨酸，可充当细胞内途径信号传导与转录活化因子的锚定位点。红细胞生成素受体的缺失会引发红白血病和家族性红细胞增多症。过量产生的红细胞会导致不良心血管事件的发生，如血栓和中风。EPOR信号可阻止神经元死亡和缺血性损伤。

EPOR, erythropoietin receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human EPOR 分子靶点信息

  • 分子名：EPOR, erythropoietin receptor
  • 别称：
    • EPO-R
    • MGC138358
    • truncated erythropoietin receptor
  • 基因序列：NCBI_Gene: 2057
  • 蛋白序列：UniProtKB: P19235

人 Human EPOR靶点分子功能（预测）

Enables erythropoietin receptor activity and identical protein binding activity. Predicted to be involved in erythropoietin-mediated signaling pathway. Predicted to act upstream of or within animal organ development and signal transduction. Located in nuclear speck and plasma membrane. Implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Biomarker of Alzheimer's disease; breast cancer; hypertension; and polycythemia vera.

小鼠 Mouse Epor 分子靶点信息

小鼠 Mouse Epor 靶点分子功能（预测）

Predicted to enable erythropoietin receptor activity and identical protein binding activity. Acts upstream of or within animal organ development and signal transduction. Predicted to be located in cytoplasm; external side of plasma membrane; and nuclear speck. Is expressed in several structures, including brain; egg cylinder; genitourinary system; germ layer; and heart and pericardium. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor).

大鼠 Rat Epor 分子靶点信息

大鼠 Rat Epor 靶点分子功能（预测）

Enables erythropoietin receptor activity. Involved in several processes, including cellular response to kainic acid; negative regulation of cell death; and negative regulation of nitric oxide biosynthetic process. Located in cytoplasm and external side of plasma membrane. Used to study high grade glioma. Biomarker of several diseases, including brain ischemia; cholangiocarcinoma; end stage renal disease; eye disease (multiple); and hepatic encephalopathy. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor).

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