EPCAM 靶点信息

EPCAM 分子靶点信息概述

  • 分子名：EPCAM, epithelial cell adhesion molecule
  • 基因家族：CD molecules; MicroRNA protein coding host genes
  • 别名：Ly74; TROP1; GA733-2; EGP34; EGP40; EGP-2; KSA; CD326; Ep-CAM; HEA125; KS1/4; MK-1; MH99; MOC31; MOC-31; 323/A3; 17-1A; TACST-1; CO-17A; ESA; BerEp4; Ber-Ep4
  • 曾用名：M4S1; MIC18; TACSTD1
  • 全称：antigen identified by monoclonal antibody AUA1; tumor-associated calcium signal transducer 1; trophoblast cell surface antigen 1

EPCAM 分子靶点综述

上皮细胞黏附分子（EpCAM），又称CD326、GA733-2抗原等，是一种I型跨膜糖蛋白。其结构包含：具有两个EGF样重复序列和半胱氨酸富集区的胞外域、跨膜域以及胞质域。该分子不仅调控细胞黏附和增殖，其过表达现象已在多种上皮源性肿瘤中被发现，并与某些肿瘤的高分期、高级别及不良预后显著相关。
研究表明，EpCAM作为一种钙离子非依赖性的同嗜性细胞黏附分子，其作用机制与已知的四大细胞黏附分子超家族均无明确关联。研究进展揭示，EpCAM除参与细胞黏附外，还在细胞增殖、迁移及分化过程中发挥重要作用。值得注意的是，近期研究发现EpCAM可作为Wnt/β-catenin信号通路的靶基因，具有潜在的预后评估价值。
该分子具有致癌潜能：当其胞内结构域被释放后，可通过激活Wnt信号通路的关键元件向细胞核转导信号。这一机制为理解EpCAM在肿瘤发生发展中的作用提供了新的分子基础。

EPCAM, epithelial cell adhesion molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human EPCAM 分子靶点信息

  • 分子名：EPCAM, epithelial cell adhesion molecule
  • 别称：
    • adenocarcinoma-associated antigen
    • Ber-Ep4
    • BerEp4
    • cell surface glycoprotein Trop-1
    • CO-17A
    • CO17-1A
    • DIAR5
    • EGP
    • EGP-2
    • EGP314
    • EGP34
    • EGP40
    • Ep-CAM
    • epithelial glycoprotein 314
    • ESA
    • GA733-2
    • hEGP-2
    • HNPCC8
    • human epithelial glycoprotein-2
    • KS1/4
    • KSA
    • LYNCH8
    • M4S1
    • major gastrointestinal tumor-associated protein GA733-2
    • membrane component, chromosome 4, surface marker (35kD glycoprotein)
    • MIC18
    • MK-1
    • MOC-31
    • TACST-1
    • TACSTD1
    • TROP1
    • trophoblast cell surface antigen 1
    • tumor-associated calcium signal transducer 1
  • 基因序列：NCBI_Gene: 4072
  • 蛋白序列：UniProtKB: P16422

人 Human EPCAM靶点分子功能（预测）

Predicted to enable cadherin binding activity involved in cell-cell adhesion. Involved in several processes, including negative regulation of cell-cell adhesion mediated by cadherin; positive regulation of stem cell proliferation; and regulation of gene expression. Located in several cellular components, including basolateral plasma membrane; bicellular tight junction; and lateral plasma membrane. Implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Biomarker of hepatocellular carcinoma.

小鼠 Mouse Epcam 分子靶点信息

  • 分子名：Epcam, epithelial cell adhesion molecule
  • 别称：
    • CD326
    • EGP-2
    • Egp314
    • Ep-CAM
    • EpCAM
    • EpCAM1
    • epithelial glycoprotein 314
    • GA733-2
    • gp40
    • Ly74
    • lymphocyte antigen 74
    • panepithelial glycoprotein 314
    • Tacstd1
    • TROP1
    • tumor-associated calcium signal transducer 1
  • 基因序列：NCBI_Gene: 17075
  • 蛋白序列：

小鼠 Mouse Epcam 靶点分子功能（预测）

Predicted to enable cadherin binding activity involved in cell-cell adhesion. Involved in ureteric bud development. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diarrhea 5 with tufting enteropathy. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule).

大鼠 Rat Epcam 分子靶点信息

  • 分子名：Epcam, epithelial cell adhesion molecule
  • 别称：
    • Egp314
    • ep-CAM
    • epithelial glycoprotein 314
    • Tacstd1
    • tumor-associated calcium signal transducer 1
  • 基因序列：NCBI_Gene: 171577
  • 蛋白序列：

大鼠 Rat Epcam 靶点分子功能（预测）

Enables cadherin binding activity involved in cell-cell adhesion. Involved in cell-cell adhesion via plasma-membrane adhesion molecules; negative regulation of apoptotic process; and positive regulation of cell motility. Located in bicellular tight junction; cell surface; and lateral plasma membrane. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule).

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