CSF1 靶点信息

CSF1 分子靶点信息概述

  • 分子名：CSF1, colony stimulating factor 1
  • 别名：M-CSF; MCSF; MGC31930
  • 全称：macrophage colony stimulating factor 1; colony stimulating factor 1 (macrophage)

CSF1 分子靶点综述

巨噬细胞集落刺激因子(M-CSF)也称为集落刺激因子1(CSF1)是由成骨细胞分泌的细胞因子。它是造血生长因子，参与单核细胞、巨噬细胞和骨髓祖细胞的增殖、分化和存活。血管壁局部产生的M-CSF会促使动脉粥样硬化的进程。M-CSF在肾病中发挥了作用，包括急性肾损伤(AKI)和慢性肾功能衰竭(CRF)。单核细胞的慢性活化会导致CRF患者多种代谢、血液和免疫异常。在AKI患者中，M-CSF可促进修复，但也有相反的作用，促使促炎性巨噬细胞增殖。

CSF1, colony stimulating factor 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CSF1 分子靶点信息

  • 分子名：CSF1, colony stimulating factor 1
  • 别称：
    • colony stimulating factor 1 (macrophage)
    • CSF-1
    • lanimostim
    • macrophage colony stimulating factor
    • macrophage colony stimulating factor 1
    • macrophage colony-stimulating factor 1
    • MCSF
    • MGC31930
  • 基因序列：NCBI_Gene: 1435
  • 蛋白序列：UniProtKB: P09603

人 Human CSF1靶点分子功能（预测）

Enables cytokine activity; growth factor activity; and protein homodimerization activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of macrophage migration. Acts upstream of or within positive regulation of cell population proliferation. Located in several cellular components, including extracellular space; nuclear body; and perinuclear region of cytoplasm. Implicated in interstitial cystitis. Biomarker of several diseases, including COVID-19; atherosclerosis; end stage renal disease; glomerulonephritis (multiple); and vesicoureteral reflux.

小鼠 Mouse Csf1 分子靶点信息

小鼠 Mouse Csf1 靶点分子功能（预测）

Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; osteoclast proliferation; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and hindlimb long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).

大鼠 Rat Csf1 分子靶点信息

大鼠 Rat Csf1 靶点分子功能（预测）

Enables identical protein binding activity. Involved in several processes, including myeloid leukocyte differentiation; odontogenesis; and ossification. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; high grade glioma; and osteopetrosis. Biomarker of systemic scleroderma. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).

CSF1 分子产品列表

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