ANGPT1 靶点信息

ANGPT1 分子靶点信息概述

  • 分子名：ANGPT1, angiopoietin 1
  • 基因家族：Receptor ligands; Fibrinogen C domain containing
  • 别名：KIAA0003; Ang1

ANGPT1 分子靶点综述

血管生成素是血管生长因子家族的一部分，在胚胎和新生血管生成中发挥作用。血管生成素细胞因子通过向血管周围的平滑肌细胞传递信号来调控微血管通透性、血管扩张和血管收缩。血管生成素-1 (ANG-1)编码498个氨基酸多肽，分子量为57 kDa，可形成二聚体、三聚体和四聚体。它在血管成熟、粘附、迁移和生存中发挥重要作用。研究显示血清中ANG-2和ANG-1的比例是增加的，这表明血管生成素和酪氨酸激酶通路的反常在血液相关疾病如糖尿病、疟疾、败血症和肺动脉高压中是常见的。

ANGPT1, angiopoietin 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ANGPT1 分子靶点信息

人 Human ANGPT1靶点分子功能（预测）

Enables receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and regulation of vascular permeability. Located in several cellular components, including extracellular space; membrane raft; and microvillus. Implicated in brain ischemia; diabetic retinopathy; and hypertension. Biomarker of carcinoma (multiple); hypertension; and ovarian cancer.

小鼠 Mouse Angpt1 分子靶点信息

小鼠 Mouse Angpt1 靶点分子功能（预测）

Enables signaling receptor binding activity. Acts upstream of or within several processes, including blood vessel development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to be located in membrane raft; microvillus; and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cardiovascular system; liver; lung; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).

大鼠 Rat Angpt1 分子靶点信息

大鼠 Rat Angpt1 靶点分子功能（预测）

Enables identical protein binding activity. Involved in several processes, including animal organ development; response to estrogen; and response to vitamin B3. Located in extracellular space. Biomarker of gastric ulcer; in situ carcinoma; myocardial infarction; nephrosis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).

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