OSM 靶点信息

OSM 分子靶点信息概述

  • 分子名：OSM, oncostatin M
  • 基因家族：Interleukin 6 type cytokine family
  • 别名：MGC20461

OSM 分子靶点综述

人抑瘤素M（Oncostatin M, OSM）是IL-6家族的一种28 kDa 多效细胞因子，是活化的T淋巴细胞、单核细胞、中性粒细胞和
一些肿瘤细胞（包括乳腺癌上皮细胞）的产物。OSM参与许多发育和免疫过程，能抑制多种肿瘤细胞系的增殖，但也会刺激AIDS-KS细胞的增殖。OSM调节内皮细胞产生的IL-6, G-CSF和GM-CSF等细胞因子。它结合的是I型OSM受体（由LIPR和IL6ST组成的异源二聚体）和II型OSM受体（由OSMR和IL6ST组成的异源二聚体）。此外，OSM参与胎儿肝细胞的成熟，从而促进肝脏的发育和再生。

OSM, oncostatin M 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human OSM 分子靶点信息

人 Human OSM靶点分子功能（预测）

Enables cytokine activity; growth factor activity; and oncostatin-M receptor binding activity. Involved in several processes, including oncostatin-M-mediated signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of protein phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space.

小鼠 Mouse Osm 分子靶点信息

小鼠 Mouse Osm 靶点分子功能（预测）

Enables cytokine activity. Acts upstream of or within several processes, including behavioral response to pain; negative regulation of meiotic nuclear division; and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in extracellular space. Is expressed in aorta-gonad-mesonephros; future spinal cord; genitourinary system; liver; and submandibular gland. Orthologous to human OSM (oncostatin M).

大鼠 Rat Osm 分子靶点信息

大鼠 Rat Osm 靶点分子功能（预测）

Predicted to enable cytokine activity; growth factor activity; and oncostatin-M receptor binding activity. Predicted to be involved in several processes, including oncostatin-M-mediated signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within several processes, including negative regulation of meiotic nuclear division; positive regulation of protein phosphorylation; and positive regulation of signal transduction. Predicted to be located in extracellular space. Orthologous to human OSM (oncostatin M).

OSM 分子产品列表

OSM 分子靶点最新资讯