NT5E, CD73 分子靶点信息

NT5E, CD73 分子靶点信息概述

  • 分子名：NT5E, 5'-nucleotidase ecto2
  • 基因家族：5'-nucleotidases; CD molecules
  • 别名：CD73; eN; eNT; CALJA
  • 曾用名：NT5
  • 全称：5' nucleotidase (CD73); 5'-nucleotidase, ecto (CD73)

NT5E, CD73 分子靶点综述

CD73又称胞外-5′-核苷酸酶(Ecto-5′-Nucleotidase)，是一种细胞表面酶，广泛表达于人体内皮细胞、淋巴细胞，如Treg等细胞表面。CD73在肿瘤微环境中过表达，有助于将具有免疫激活作用的ATP转化为腺苷，促进肿瘤生长。

NT5E, 5'-nucleotidase ecto 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NT5E, CD73 分子靶点信息

  • 分子名：NT5E, 5'-nucleotidase ecto2
  • 别称：
    • 5 nucleotidase
    • 5' nucleotidase (CD73)
    • 5'-NT
    • 5'-nucleotidase
    • 5'-nucleotidase, ecto (CD73)
    • CALJA
    • CD73
    • E5NT
    • ecto-5'-nucleotidase
    • eN
    • eNT
    • NT
    • NT5
    • NTE
    • Purine 5-Prime-Nucleotidase
  • 基因序列：NCBI_Gene: 4907
  • 蛋白序列：UniProtKB: P21589

人 Human NT5E, CD73靶点分子功能（预测）

Enables several functions, including 5'-deoxynucleotidase activity; 5'-nucleotidase activity; and zinc ion binding activity. Involved in several processes, including ATP metabolic process; leukocyte cell-cell adhesion; and response to ATP. Located in cytosol; membrane; and nucleoplasm. Is active in plasma membrane. Implicated in hereditary arterial and articular multiple calcification syndrome.

小鼠 Mouse Nt5e/CD73 分子靶点信息

  • 分子名：Nt5e, 5' nucleotidase, ecto
  • 别称：
    • 2210401F01Rik
    • 5' nucleotidase
    • AI447961
    • CD73
    • ecto-5'-nucleotidase
    • expressed sequence AI447961
    • Nt5
    • RIKEN cDNA 2210401F01 gene
  • 基因序列：NCBI_Gene: 23959
  • 蛋白序列：

    小鼠 Mouse Nt5e/CD73 靶点分子功能（预测）

    Enables 5'-nucleotidase activity. Involved in calcium ion homeostasis; inhibition of non-skeletal tissue mineralization; and purine ribonucleotide catabolic process. Acts upstream of or within adenosine biosynthetic process and negative regulation of inflammatory response. Located in plasma membrane. Is active in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and musculoskeletal system. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto).

大鼠 Rat Nt5e, CD73 分子靶点信息

  • 分子名：Nt5e, 5' nucleotidase, ecto
  • 别称：
    • 5 nucleotidase
    • 5 nucleotidase ecto
    • 5' nucleotidase ecto
    • 5'-NT
    • 5'-nucleotidase
    • CD73
    • ecto-5'-nucleotidase
    • MGC112615
    • Nt5
  • 基因序列：NCBI_Gene: 58813
  • 蛋白序列：

大鼠 Rat Nt5e, CD73 靶点分子功能（预测）

Enables 5'-nucleotidase activity and ferrous iron binding activity. Involved in nucleobase-containing small molecule metabolic process; positive regulation of lipid biosynthetic process; and response to aluminum ion. Located in cell surface and synaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto).

NT5E, CD73 分子产品列表

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