HIF1A 靶点信息

HIF1A 分子靶点信息概述

  • 分子名：HIF1A, hypoxia inducible factor 1 subunit alpha
  • 基因家族：Basic helix-loop-helix proteins; PAS domain containing
  • 别名：MOP1; HIF-1alpha; PASD8; HIF1; bHLHe78
  • 全称：hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); PAS domain-containing protein 8; Class E basic helix-loop-helix protein 78; Member of PAS protein 1

HIF1A 分子靶点综述

低氧诱导转录因子1α(HIF-1α/HIF1A)是转录因子异二聚体HIF-1α/β的调控成员。作为对缺氧的适应性反应的主要转录调节因子，HIF-1α在低氧条件下，与许多基因启动子中的缺氧反应元件(HREs)结合，激活40多个基因的转录，包括促红细胞生成素、葡萄糖转运蛋白、糖酵解酶、血管内皮生长因子、HILPDA和其他其蛋白产物增加氧输送或促进代谢对低氧适应的基因。HIF-1α还在胚胎血管生成、肿瘤血管生成和缺血性疾病的病理生理中起重要作用以及参与缺氧时神经元内线粒体的轴突分布和运输。
HIF-1α普遍存在于人和哺乳动物细胞内，常氧下(21% O2)也有表达，但合成的HIF-1α蛋白很快被细胞内氧依赖性泛素蛋白酶降解途径所降解，只有在缺氧条件下HIF-1α才可稳定表达。

HIF1A, hypoxia inducible factor 1 subunit alpha 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human HIF1A 分子靶点信息

  • 分子名：HIF1A, hypoxia inducible factor 1 subunit alpha
  • 别称：
    • ARNT interacting protein
    • ARNT-interacting protein
    • basic-helix-loop-helix-PAS protein MOP1
    • bHLHe78
    • class E basic helix-loop-helix protein 78
    • HIF-1-alpha
    • HIF-1A
    • HIF-1alpha
    • HIF1
    • HIF1-ALPHA
    • hypoxia inducible factor 1 alpha subunit
    • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    • hypoxia-inducible factor 1 alpha isoform I.3
    • hypoxia-inducible factor 1-alpha
    • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    • hypoxia-inducible factor1alpha
    • member of PAS protein 1
    • member of PAS superfamily 1
    • MOP1
    • PAS domain-containing protein 8
    • PAS domain-containing protein 8", "Class E basic helix-loop-helix protein 78", "Member of PAS protein 1
    • PASD8
  • 基因序列：NCBI_Gene: 3091
  • 蛋白序列：UniProtKB: Q16665

人 Human HIF1A靶点分子功能（预测）

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Hsp90 protein binding activity; and enzyme binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including oxygen homeostasis; regulation of gene expression; and vascular endothelial growth factor production. Acts upstream of or within regulation of transcription, DNA-templated and response to hypoxia. Located in chromatin; cytosol; and nuclear body. Part of RNA polymerase II transcription regulator complex. Implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Biomarker of several diseases, including arthritis (multiple); gastrointestinal system cancer (multiple); invasive ductal carcinoma; kidney cancer (multiple); and morbid obesity.

小鼠 Mouse Hif1a 分子靶点信息

小鼠 Mouse Hif1a 靶点分子功能（预测）

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including connective tissue replacement involved in inflammatory response wound healing; positive regulation of autophagy of mitochondrion; and positive regulation of miRNA transcription. Acts upstream of or within several processes, including circulatory system development; negative regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Located in euchromatin; motile cilium; and nuclear speck. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; lung; and sensory organ. Used to study glycogen storage disease V and glycogen storage disease VII. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).

大鼠 Rat Hif1a 分子靶点信息

  • 分子名：Hif1a, hypoxia inducible factor 1 subunit alpha
  • 别称：
    • HIF-1 alpha
    • HIF-1-alpha
    • HIF1 alpha
    • HIF1-alpha
    • hypoxia inducible factor 1 alpha subunit
    • hypoxia inducible factor 1, alpha subunit
    • hypoxia-inducible factor 1 alpha
    • hypoxia-inducible factor 1-alpha
    • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    • MOP1
  • 基因序列：NCBI_Gene: 29560
  • 蛋白序列：

大鼠 Rat Hif1a 靶点分子功能（预测）

Enables sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to carbon monoxide; regulation of apoptotic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Used to study acute kidney failure; brain ischemia; diabetic retinopathy; hepatocellular carcinoma; and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; decubitus ulcer; ischemia (multiple); and kidney failure (multiple). Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).

HIF1A 分子产品列表

HIF1A 分子靶点最新资讯