MIF 靶点信息

MIF 分子靶点信息概述

  • 分子名：MIF, macrophage migration inhibitory factor
  • 别名：GIF
  • 曾用名：GLIF
  • 全称：glycosylation-inhibiting factor; phenylpyruvate tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor)

MIF 分子靶点综述

巨噬细胞游走抑制因子(MIF)是先天免疫的重要调节子。细菌抗原刺激白细胞释放MIF到血流中。循环的MIF结合其它免疫细胞上的CD74进而引发急性免疫反应，因此MIF是一种炎性细胞因子。此外，糖皮质激素也可刺激白细胞释放MIF。MIF通过抑制糖皮质激素的消炎效果来调节巨噬细胞在宿主防御中的功能。MIF是一种与类风湿关节炎严重程度相关的炎性介质。精神分裂症患者血浆中的MIF蛋白水平会升高，包括在疾病的早期阶段，但是这种现象的临床意义还未确定。MIF同样可诱导脓毒症过程中的心脏变化。另外，有证据表明，MIF产量和结肠癌的转移潜能之间存在一定关联。

MIF, macrophage migration inhibitory factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MIF 分子靶点信息

  • 分子名：MIF, macrophage migration inhibitory factor
  • 别称：
    • GIF
    • GLIF
    • L-dopachrome isomerase
    • L-dopachrome tautomerase
    • macrophage migration inhibitory factor (glycosylation-inhibiting factor)
    • MMIF
    • phenylpyruvate tautomerase
  • 基因序列：NCBI_Gene: 4282
  • 蛋白序列：UniProtKB: P14174

人 Human MIF靶点分子功能（预测）

Enables several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; extracellular space; and nucleoplasm. Implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Biomarker of artery disease (multiple); asthma; lung disease (multiple); obesity; and rhinitis.

小鼠 Mouse Mif 分子靶点信息

小鼠 Mouse Mif 靶点分子功能（预测）

Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cell aging; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor).

大鼠 Rat Mif 分子靶点信息

  • 分子名：Mif, macrophage migration inhibitory factor
  • 别称：
    • glutathione-binding 13 kDa protein
    • L-dopachrome isomerase
    • L-dopachrome tautomerase
    • LOC103694877
    • macrophage migration inhibitory factor (glycosylation-inhibiting factor)
    • MGC72801
    • phenylpyruvate tautomerase
  • 基因序列：NCBI_Gene: 81683
  • 蛋白序列：

大鼠 Rat Mif 靶点分子功能（预测）

Predicted to enable several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of transport; response to steroid hormone; and response to vitamin. Located in cytoplasm; extracellular space; and nucleus. Used to study several diseases, including acute necrotizing pancreatitis; cardiomyopathy (multiple); lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor).

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