FGF7 靶点信息

FGF7 分子靶点信息概述

  • 分子名：FGF7, fibroblast growth factor 7
  • 基因家族：Receptor ligands; Fibroblast growth factor family
  • 别名：KGF
  • 全称：keratinocyte growth factor; fibroblast growth factor 7 (keratinocyte growth factor)

FGF7 分子靶点综述

角质细胞生长因子(KGF)，也被称为成纤维细胞生长因子7(FGF-7)，是伤口愈合上皮化阶段的生长因子。在这个阶段中，角质细胞覆盖伤口，形成上皮细胞。成纤维细胞、胚胎间充质细胞和平滑肌细胞可表达KGF。KGF是小信号分子，需结合成纤维细胞生长因子受体2b(FGFR2b)才能产生信号。研究显示，KGF是许多不同上皮细胞类型的旁分泌效应者。KGF不仅可诱导细胞增殖，还可促进上皮细胞分化。细胞因子如IL-1α和IL-1β、IL-6不仅激活局部结缔组织细胞，清除异物和重塑组织，同样可刺激成纤维细胞KGF的产生，促进再上皮化和伤口愈合。

FGF7, fibroblast growth factor 7 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FGF7 分子靶点信息

  • 分子名：FGF7, fibroblast growth factor 7
  • 别称：
    • FGF-7
    • HBGF-7
    • heparin-binding growth factor 7
    • keratinocyte growth factor
    • KGF
  • 基因序列：NCBI_Gene: 2252
  • 蛋白序列：UniProtKB: P21781

人 Human FGF7靶点分子功能（预测）

Enables chemoattractant activity. Involved in several processes, including positive regulation of keratinocyte migration; positive regulation of keratinocyte proliferation; and protein localization to cell surface. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of epithelial cell proliferation involved in lung morphogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Biomarker of several diseases, including inflammatory bowel disease (multiple); leiomyoma; prostatic hypertrophy; reproductive organ cancer (multiple); and severe acute respiratory syndrome.

小鼠 Mouse Fgf7 分子靶点信息

小鼠 Mouse Fgf7 靶点分子功能（预测）

Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within morphogenesis of an epithelium; positive regulation of epithelial cell proliferation; and regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling. Located in Golgi apparatus and extracellular region. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and integumental system. Orthologous to human FGF7 (fibroblast growth factor 7).

大鼠 Rat Fgf7 分子靶点信息

  • 分子名：Fgf7, fibroblast growth factor 7
  • 别称：
    • FGF-7
    • Fgf5b
    • fibroblast growth factor 5b
    • HBGF-7
    • heparin-binding growth factor 7
    • keratinocyte growth factor
    • Keratinocyte Growth Factor Fgf-7
    • Kgf
    • KGF/FGF7
  • 基因序列：NCBI_Gene: 29348
  • 蛋白序列：

大鼠 Rat Fgf7 靶点分子功能（预测）

Enables growth factor activity; heparin binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including ovarian follicle development; phosphatidylcholine biosynthetic process; and surfactant homeostasis. Located in extracellular space. Orthologous to human FGF7 (fibroblast growth factor 7).

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