CCN2 靶点信息

CCN2 分子靶点信息概述

  • 分子名：CCN2, cellular communication network factor 2
  • 基因家族：Cellular communication network factors
  • 别名：IGFBP8
  • 曾用名：CTGF
  • 全称：connective tissue growth factor

CCN2 分子靶点综述

结缔组织生长因子(CTGF)是CNN家族中的细胞基质蛋白。CTGF的胞外部分包括四个保守的、富含半胱氨酸的结构域：胰岛素样生长因子结合蛋白(IGFBP)结构域、血管性血友病C型重复序列(vWC)结构域、血小板反应蛋白1型重复序列(TSR)结构域以及含有半胱氨酸基元的C端结构域(CT)。CTGF在许多生物过程中发挥重要作用，包括细胞粘附、迁移、增殖、血管生成、骨骼发育和组织创伤修复。监测血清中CTGF水平可为一些病理情况如恶性肿瘤、糖尿病肾病、视网膜病变、纤维化、关节炎、胰腺癌和心血管疾病，提供更详细的见解。

CCN2, cellular communication network factor 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CCN2 分子靶点信息

  • 分子名：CCN2, cellular communication network factor 2
  • 别称：
    • CCN family member 2
    • connective tissue growth factor
    • CTGF
    • HCS24
    • hypertrophic chondrocyte-specific protein 24
    • IBP-8
    • IGF-binding protein 8
    • IGFBP-8
    • IGFBP8
    • insulin-like growth factor-binding protein 8
    • MGC102839
    • NOV2
  • 基因序列：NCBI_Gene: 1490
  • 蛋白序列：UniProtKB: P29279

人 Human CCN2靶点分子功能（预测）

Enables protein C-terminus binding activity. Involved in positive regulation of MAPK cascade; positive regulation of cell differentiation; and positive regulation of stress fiber assembly. Colocalizes with collagen-containing extracellular matrix. Biomarker of ovarian cancer.

小鼠 Mouse Ccn2 分子靶点信息

小鼠 Mouse Ccn2 靶点分子功能（预测）

Enables heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2).

大鼠 Rat Ccn2 分子靶点信息

  • 分子名：Ccn2, cellular communication network factor 2
  • 别称：
    • CCN family member 2
    • connective tissue growth factor
    • connective tissue growth-related protein
    • Ctgf
    • CTGRP
  • 基因序列：NCBI_Gene: 64032
  • 蛋白序列：

大鼠 Rat Ccn2 靶点分子功能（预测）

Enables fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cis-Golgi network; and perinuclear region of cytoplasm. Used to study endomyocardial fibrosis. Biomarker of several diseases, including artery disease (multiple); lung disease (multiple); membranoproliferative glomerulonephritis; primary biliary cholangitis; and restrictive cardiomyopathy (multiple). Orthologous to human CCN2 (cellular communication network factor 2).

CCN2 分子产品列表

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