BMP4 靶点信息

BMP4 分子靶点信息概述

  • 分子名：BMP4, bone morphogenetic protein 4
  • 基因家族：Bone morphogenetic proteins
  • 曾用名：BMP2B

BMP4 分子靶点综述

BMP是分泌的信号分子，包含TGF-β超家族的一个亚家族，最初被鉴定为软骨和骨形成的调节剂。通常，BMP与各种组织和器官的胚胎发生和形态发生有关。BMP-2，BMP-4和BMP-7，在中胚层胚层的造血组织规范中起作用。它们调节来自成年和新生儿来源的高度纯化的原始人类造血细胞的增殖和分化。BMP-4，也称为骨形态发生蛋白4，它形成二硫键连接的同型二聚体。已证明BMP-4也参与交感神经元的分化。它增强了神经c细胞培养物中肾上腺素能交感神经元的形成。

BMP4, bone morphogenetic protein 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human BMP4 分子靶点信息

  • 分子名：BMP4, bone morphogenetic protein 4
  • 别称：
    • BMP-2B
    • BMP-4
    • BMP2B
    • BMP2B1
    • bone morphogenetic protein 2B
    • bone morphogenetic protein 4 preproprotein
    • MCOPS6
    • OFC11
    • ZYME
  • 基因序列：NCBI_Gene: 652
  • 蛋白序列：UniProtKB: P12644

人 Human BMP4靶点分子功能（预测）

Enables BMP receptor binding activity; co-receptor binding activity; and receptor ligand activity. Involved in several processes, including animal organ development; negative regulation of cell population proliferation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of transcription by RNA polymerase II; and respiratory system development. Located in extracellular space. Implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Biomarker of several diseases, including Barrett's esophagus; eye disease (multiple); myositis ossificans; progressive osseous heteroplasia; and prolactinoma.

小鼠 Mouse Bmp4 分子靶点信息

小鼠 Mouse Bmp4 靶点分子功能（预测）

Enables heparin binding activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of morphogenesis of a branching structure. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of animal organ morphogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Axenfeld-Rieger syndrome type 3; atrioventricular septal defect; cleft palate-lateral synechia syndrome; fibrodysplasia ossificans progressiva; and urinary system disease. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4).

大鼠 Rat Bmp4 分子靶点信息

大鼠 Rat Bmp4 靶点分子功能（预测）

Enables growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4).

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