APOA1 靶点信息

APOA1 分子靶点信息概述

  • 分子名：APOA1, apolipoprotein A1
  • 基因家族：Apolipoproteins
  • 全称：apolipoprotein A-I

APOA1 分子靶点综述

载脂蛋白A1 (Apo A1)是血浆中高密度脂蛋白(HDL)的主要蛋白成分。小肠上皮细胞分泌的乳糜微粒也包含Apo A1，但是它很快就转移到血液的HDL中。该蛋白在脂质代谢中有特定作用，它促进脂肪流出，包括将组织中的胆固醇转运至肝脏完成排泄。它是卵磷脂胆固醇脂酰转移酶的辅因子，负责大部分血浆胆固醇酯的形成。Apo A1也是前列环素的稳定因子，因此可能有抗凝血功能。Apo A1通常作为预测心血管疾病的生物标志物。相比于其它脂质测定，Apo B-100/Apo A1比率已被报道是一种预测心肌梗死风险的有效预测工具。编码Apo A1基因的缺失与HDL缺陷，包括丹吉尔疾病，以及系统性非神经性淀粉样变性有关。

APOA1, apolipoprotein A1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human APOA1 分子靶点信息

  • 分子名：APOA1, apolipoprotein A1
  • 别称：
    • apo-AI
    • apo(a)
    • apoA-I
    • apolipoprotein A-I
    • HPALP2
    • MGC117399
  • 基因序列：NCBI_Gene: 335
  • 蛋白序列：UniProtKB: P02647

人 Human APOA1靶点分子功能（预测）

Enables several functions, including amyloid-beta binding activity; cholesterol binding activity; and signaling receptor binding activity. Contributes to cholesterol transfer activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of Rho protein signal transduction. Acts upstream of or within cholesterol transport. Located in endocytic vesicle and extracellular space. Part of spherical high-density lipoprotein particle and very-low-density lipoprotein particle. Implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; liver disease (multiple); and neurodegenerative disease (multiple).

小鼠 Mouse Apoa1 分子靶点信息

小鼠 Mouse Apoa1 靶点分子功能（预测）

Enables several functions, including cholesterol transfer activity; high-density lipoprotein particle binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cholesterol biosynthetic process; cholesterol efflux; and regulation of intestinal cholesterol absorption. Located in extracellular space. Is expressed in several structures, including adrenal gland; gonad; gut; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).

大鼠 Rat Apoa1 分子靶点信息

  • 分子名：Apoa1, apolipoprotein A1
  • 别称：
    • apo-AI
    • apoA-I
    • apolipoprotein A-1
    • apolipoprotein A-I
    • preproapolipoprotein A-I
  • 基因序列：NCBI_Gene: 25081
  • 蛋白序列：UniProtKB: P04639

大鼠 Rat Apoa1 靶点分子功能（预测）

Enables amyloid-beta binding activity; cholesterol transfer activity; and lipase inhibitor activity. Involved in several processes, including lipid transport; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface; extracellular space; and nucleus. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including fatty liver disease (multiple); hypertension; major depressive disorder; ocular hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).

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