文章目录[隐藏]
TIGIT 分子靶点信息概述
- 分子名：TIGIT, T cell immunoreceptor with Ig and ITIM domains
- 基因家族：V-set domain containing
- 别名：FLJ39873; DKFZp667A205
- 曾用名：VSIG9; VSTM3
- 全称：VSIG9, VSTM3
TIGIT 分子靶点综述
TIGIT，全称为T细胞免疫球蛋白和ITIM结构域蛋白，又称Vsig9、Vstm3或WUCAM，是脊髓灰质炎病毒受体(PVR)/Nectin家族的成员，也是免疫球蛋白超家族的成员之一。由细胞外的免疫球蛋白(IgV)结构域，I型跨膜结构域和细胞内的ITIM及免疫球蛋白酪氨酸尾(ITT)基序结构共同组成。TIGIT仅限于在淋巴细胞上表达，其中表达最多的为CD4+的调节T细胞，CD4+的滤泡辅助性T细胞，CD8+的效应T细胞和自然杀伤(NK)细胞。
TIGIT, T cell immunoreceptor with Ig and ITIM domains 分子靶点种属信息
人 Human TIGIT 分子靶点信息
- 分子名：TIGIT, T cell immunoreceptor with Ig and ITIM domains
- 别称：
- DKFZp667A205
- FLJ39873
- T-cell immunoreceptor with Ig and ITIM domains
- V-set and immunoglobulin domain containing 9
- V-set and immunoglobulin domain-containing protein 9
- V-set and transmembrane domain containing 3
- V-set and transmembrane domain-containing protein 3
- VSIG9
- VSIG9, VSTM3
- VSTM3
- Washington University cell adhesion molecule
- WUCAM
- 基因序列：NCBI_Gene: 201633
- 蛋白序列：UniProtKB: Q495A1
人 Human TIGIT靶点分子功能（预测）
Enables identical protein binding activity and signaling receptor binding activity. Involved in negative regulation of interleukin-12 production and positive regulation of interleukin-10 production. Acts upstream of or within negative regulation of T cell activation. Located in cell surface.
小鼠 Mouse Tigit 分子靶点信息
- 分子名：Tigit, T cell immunoreceptor with Ig and ITIM domains
- 别称：
- ENSMUSG00000071552
- predicted gene, ENSMUSG00000071552
- V-set and transmembrane domain containing 3
- Vstm3
- 基因序列：NCBI_Gene: 100043314
- 蛋白序列：
小鼠 Mouse Tigit 靶点分子功能（预测）
Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).
大鼠 Rat Tigit 分子靶点信息
- 分子名：Tigit, T cell immunoreceptor with Ig and ITIM domains
- 别称：
- LOC363784
- RGD1563191
- similar to hypothetical protein
- T-cell immunoreceptor with Ig and ITIM domains
- 基因序列：NCBI_Gene: 363784
- 蛋白序列：UniProtKB: D3ZTQ2
大鼠 Rat Tigit 靶点分子功能（预测）
Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in negative regulation of T cell activation; negative regulation of interleukin-12 production; and positive regulation of interleukin-10 production. Predicted to be integral component of membrane. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).
