RETN 靶点信息

RETN 分子靶点信息概述

  • 分子名：RETN, resistin
  • 别名：FIZZ3; ADSF; RETN1

RETN 分子靶点综述

抵抗素(Resistin)是一种富含半胱氨酸的来源于脂肪的肽激素，在人类中由RETN基因编码。在灵长类动物、猪和狗中，Resistin是由免疫细胞和上皮细胞分泌的。而在啮齿类动物中，它是由脂肪组织分泌的。人Resistin前肽的长度为108个氨基酸残基，小鼠和大鼠的长度则为114个氨基酸残基，分子量大约为12.5kDa。Resistin加速了动脉中低密度脂蛋白的积累，增加了人们患心脏病的风险。它会不良影响他汀类药物的作用效果，这类药物主要是降低胆固醇，用来治疗和预防心血管疾病的。最近研究发现Resistin还参与炎症反应。Resistin确实具有促炎性细胞因子的功能，并且可以作为炎症疾病中的一个重要节点。Resistin是一种脂肪来源的激素（类似于细胞因子），关于它参与肥胖和II型糖尿病这一生理作用一直是备受争议的话题。

RETN, resistin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human RETN 分子靶点信息

  • 分子名：RETN, resistin
  • 别称：
    • adipose tissue-specific secretory factor
    • ADSF
    • C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1
    • c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
    • cysteine-rich secreted protein A12-alpha-like 2
    • cysteine-rich secreted protein FIZZ3
    • FIZZ3
    • found in inflammatory zone 3
    • MGC126603
    • MGC126609
    • resistin delta2
    • RETN1
    • RSTN
    • XCP1
  • 基因序列：NCBI_Gene: 56729
  • 蛋白序列：UniProtKB: Q9HD89

人 Human RETN靶点分子功能（预测）

Predicted to enable hormone activity. Predicted to be involved in several processes, including fat cell differentiation; negative regulation of feeding behavior; and positive regulation of cell communication. Located in extracellular exosome. Implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including diabetes mellitus (multiple); diabetic neuropathy; heart disease (multiple); kidney failure (multiple); and systemic lupus erythematosus.

小鼠 Mouse Retn 分子靶点信息

小鼠 Mouse Retn 靶点分子功能（预测）

Predicted to enable hormone activity. Predicted to be involved in several processes, including positive regulation of cell communication; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Is expressed in adipose tissue; gonadal fat pad; inguinal fat pad; renal fat pad; and white fat. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin).

大鼠 Rat Retn 分子靶点信息

大鼠 Rat Retn 靶点分子功能（预测）

Predicted to enable hormone activity. Involved in several processes, including positive regulation of cell communication; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in extracellular space and nucleus. Used to study colitis. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin).

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