APOM 靶点信息

APOM 分子靶点信息概述

  • 分子名：APOM, apolipoprotein M
  • 基因家族：Apolipoproteins; Lipocalins
  • 别名：G3a; NG20

APOM 分子靶点综述

载脂蛋白M (Apo M)在人类中由APOM基因编码。该基因编码的蛋白是一种载脂蛋白，是载脂蛋白家族中的一员。研究发现Apo M与高密度脂蛋白有关，与低密度脂蛋白和富含甘油三酯的脂蛋白关联程度稍低。Apo M通过质膜分泌，但仍结合在膜上，参与脂质运输。研究发现APOM基因有2个转录变体，可编码2个不同异构体，但只有其中一个被完全鉴定。Apo M的平均分子量为21253 Da，单一同位素的分子量为21239 Da。

APOM, apolipoprotein M 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human APOM 分子靶点信息

  • 分子名：APOM, apolipoprotein M
  • 别称：
    • alternative name: G3a, NG20
    • apo-M
    • G3a
    • HSPC336
    • MGC22400
    • NG20
    • NG20-like protein
  • 基因序列：NCBI_Gene: 55937
  • 蛋白序列：UniProtKB: O95445

人 Human APOM靶点分子功能（预测）

Enables antioxidant activity; lipid transporter activity; and phospholipid binding activity. Involved in cholesterol efflux; high-density lipoprotein particle remodeling; and negative regulation of plasma lipoprotein oxidation. Part of high-density lipoprotein particle; low-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus.

小鼠 Mouse Apom 分子靶点信息

小鼠 Mouse Apom 靶点分子功能（预测）

Enables antioxidant activity. Involved in several processes, including cholesterol efflux; high-density lipoprotein particle clearance; and plasma lipoprotein particle organization. Acts upstream of or within lipoprotein metabolic process and reverse cholesterol transport. Located in extracellular region. Part of discoidal high-density lipoprotein particle. Is expressed in several structures, including gut; liver; male reproductive gland or organ; and urinary system. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M).

大鼠 Rat Apom 分子靶点信息

大鼠 Rat Apom 靶点分子功能（预测）

Predicted to enable antioxidant activity; lipid transporter activity; and phospholipid binding activity. Involved in response to glucose. Located in extracellular space. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M).

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