CX3CL1 靶点信息

CX3CL1 分子靶点信息概述

  • 分子名：CX3CL1, C-X3-C motif chemokine ligand 1
  • 基因家族：Chemokine ligands
  • 别名：NTN; C3Xkine; ABCD-3; CXC3C; CXC3
  • 曾用名：SCYD1
  • 全称：fractalkine; neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); chemokine (C-X3-C motif) ligand 1

CX3CL1 分子靶点综述

趋化因子(C-X3-C基序)配体1(CX3CL1)，又名fractalkine，是一个由373个氨基酸组成的大分子细胞因子蛋白，也是CX3C趋化因子家族中唯一一个已知成员。可溶性CX3CL1存在于血清、尿液、脑脊液、羊水和滑液中，主要由血管内皮、平滑肌、神经元和树突状细胞表达。炎性细胞因子如TNF-α和IFN-γ可诱导大多数CX3CL1的表达。CX3CL1是通过与趋化因子受体CX3CR1的相互作用来发挥其粘附和迁移功能。可溶性CX3XL1可强烈趋化T细胞和单核细胞，而细胞结合的趋化因子促进白细胞强有力粘附到活化的内皮细胞上。CX3CL1可能与抗肿瘤活性有关，在消退正常炎症过程如伤口愈合中有重要作用。CX3CL1对某些条件的发病具有促进作用。

CX3CL1, C-X3-C motif chemokine ligand 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CX3CL1 分子靶点信息

  • 分子名：CX3CL1, C-X3-C motif chemokine ligand 1
  • 别称：
    • ABCD-3
    • C-X3-C motif chemokine 1
    • C3Xkine
    • chemokine (C-X3-C motif) ligand 1
    • CX3C membrane-anchored chemokine
    • CXC3
    • CXC3C
    • fractalkine
    • neurotactin
    • NTN
    • NTT
    • SCYD1
    • small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)
    • small inducible cytokine subfamily D (Cys-X3-Cys), member-1
    • small-inducible cytokine D1
  • 基因序列：NCBI_Gene: 6376
  • 蛋白序列：UniProtKB: P78423

人 Human CX3CL1靶点分子功能（预测）

Enables signaling receptor binding activity. Involved in several processes, including regulation of cell migration; regulation of gene expression; and regulation of signal transduction. Located in cell surface; extracellular region; and membrane. Is integral component of membrane. Implicated in Cor pulmonale and common cold. Biomarker of several diseases, including chronic fatigue syndrome; myositis (multiple); polyarteritis nodosa; pulmonary hypertension; and rheumatoid arthritis.

小鼠 Mouse Cx3cl1 分子靶点信息

小鼠 Mouse Cx3cl1 靶点分子功能（预测）

Enables CX3C chemokine receptor binding activity and chemokine activity. Acts upstream of or within several processes, including angiogenesis involved in wound healing; leukocyte chemotaxis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; nose; and respiratory system. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1).

大鼠 Rat Cx3cl1 分子靶点信息

  • 分子名：Cx3cl1, C-X3-C motif chemokine ligand 1
  • 别称：
    • C-X3-C motif chemokine 1
    • chemokine (C-X3-C motif) ligand 1
    • Cx3c
    • CX3C membrane-anchored chemokine
    • fractalkine
    • neurotactin
    • Scyd1
    • small inducible cytokine subfamily D 1
    • small inducible cytokine subfamily D, 1
    • small-inducible cytokine D1
  • 基因序列：NCBI_Gene: 89808
  • 蛋白序列：

大鼠 Rat Cx3cl1 靶点分子功能（预测）

Enables chemokine activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of gene expression; and regulation of signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and perinuclear region of cytoplasm. Used to study acute pancreatitis; ischemia; and status epilepticus. Biomarker of several diseases, including borna disease; brain disease (multiple); liver disease (multiple); lung disease (multiple); and pulmonary hypertension. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1).

CX3CL1 分子产品列表

CX3CL1 分子靶点最新资讯