TGFB2 靶点信息

TGFB2 分子靶点信息概述

  • 分子名：TGFB2, transforming growth factor beta 2
  • 基因家族：Transforming growth factor beta family
  • 全称：prepro-transforming growth factor beta-2; transforming growth factor, beta 2

TGFB2 分子靶点综述

转化生长因子β2(TGF-β2)前体蛋白由19个氨基酸的信号肽、283个氨基酸的前区和112个氨基酸的成熟区组成。人TGF-β2成熟区与人TGF-β1和TGF-β3的同源性分别为71%和80%，与小鼠TGF-β2的同源性为97%。它可由各类细胞表达，包括破骨细胞、胸腺上皮细胞、角蛋白细胞、肝细胞、胃的主细胞和卫星细胞等。TGF-β2具有显著的种属交叉生物活性，如人TGF-β2对小鼠细胞具有活性，而猪TGF-β2对兔细胞具有活性等。TGF-β2具有4种基本活性：是大部分类型细胞的生长抑制因子；可增强细胞外基质的沉积；具有免疫抑制作用，抑制抗原递呈细胞表达IL-12和CD40L，上调IL-10分泌；在胚胎发育期表达于离散区域，如上皮、心肌、手足的软骨和骨骼、以及神经系统，提示其具有特异性的功能。

TGFB2, transforming growth factor beta 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TGFB2 分子靶点信息

  • 分子名：TGFB2, transforming growth factor beta 2
  • 别称：
    • BSC-1 cell growth inhibitor
    • cetermin
    • G-TSF
    • glioblastoma-derived T-cell suppressor factor
    • LDS4
    • MGC116892
    • polyergin
    • prepro-transforming growth factor beta-2
    • TGF-beta-2
    • TGF-beta2
    • transforming growth factor beta-2
    • transforming growth factor beta-2 proprotein
    • transforming growth factor, beta 2
  • 基因序列：NCBI_Gene: 7042
  • 蛋白序列：UniProtKB: P61812

人 Human TGFB2靶点分子功能（预测）

Enables amyloid-beta binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of signal transduction. Located in collagen-containing extracellular matrix and extracellular space. Implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Biomarker of colon carcinoma; colorectal cancer; and liver cirrhosis.

小鼠 Mouse Tgfb2 分子靶点信息

小鼠 Mouse Tgfb2 靶点分子功能（预测）

Predicted to enable several functions, including amyloid-beta binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including animal organ development; regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and tube morphogenesis. Acts upstream of or within several processes, including animal organ development; neuron differentiation; and positive regulation of apoptotic process. Located in several cellular components, including axon; endosome; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Loeys-Dietz syndrome. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2).

大鼠 Rat Tgfb2 分子靶点信息

大鼠 Rat Tgfb2 靶点分子功能（预测）

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of release of sequestered calcium ion into cytosol; and regulation of apoptotic process. Located in several cellular components, including basement membrane; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2).

TGFB2 分子产品列表

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“管”好这种淋巴细胞，会让肿瘤免疫治疗更有效！