文章目录[隐藏]
ERBB3 分子靶点信息概述
- 分子名：ERBB3, erb-b2 receptor tyrosine kinase 3
- 基因家族：Erb-b2 receptor tyrosine kinases
- 别名：LCCS2; HER3; HER-3
- 曾用名：LCCS2
- 全称：lethal congenital contracture syndrome 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; human epidermal growth factor receptor 3
ERBB3 分子靶点综述
人表皮生长因子受体3 (human epidermal growth factor receptor 3, Her3)，也称ErbB3，是一种I型跨膜糖蛋白，是酪氨酸激酶受体ErbB家族的成员。ErbB3结合神经调节蛋白NRG1和NRG2，但缺少一个有效的激酶结构域；与另一个ErbB受体的异二聚作用是信号转导所必需的。ErbB3在雪旺细胞、神经嵴细胞、心脏瓣膜和交感神经系统的发育中起重要作用。这种基因的扩增和/或其蛋白的过度表达在许多癌症中都有报道，包括前列腺癌、膀胱癌和乳腺癌。ErbB3在多种肿瘤中高表达，激活时可引起肿瘤增殖及药物抵抗性。E3泛素连接酶、单克隆抗体以及microRNA是当前调节ErbB3表达及功能的主要分子标志物。
ERBB3, erb-b2 receptor tyrosine kinase 3 分子靶点种属信息
人 Human ERBB3 分子靶点信息
- 分子名：ERBB3, erb-b2 receptor tyrosine kinase 3
- 别称：
- avian erythroblastosis oncogene b 3
- c-erbB-3
- c-erbB3
- ErbB-3
- erbB3-S
- FERLK
- HER3
- human epidermal growth factor receptor 3
- LCCS2
- MDA-BF-1
- MGC88033
- p180-ErbB3
- p45-sErbB3
- p85-sErbB3
- proto-oncogene-like protein c-ErbB-3
- receptor tyrosine-protein kinase erbB-3
- tyrosine kinase-type cell surface receptor HER3
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
- VSCN1
- 基因序列：NCBI_Gene: 2065
- 蛋白序列：UniProtKB: P21860
人 Human ERBB3靶点分子功能（预测）
Enables several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and protein heterodimerization activity. Involved in several processes, including extrinsic apoptotic signaling pathway in absence of ligand; phosphatidylinositol 3-kinase signaling; and positive regulation of protein tyrosine kinase activity. Located in basolateral plasma membrane and extracellular space. Part of ERBB3:ERBB2 complex. Implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Biomarker of carcinoma (multiple); ductal carcinoma in situ; prostate cancer; and urinary bladder cancer.
ERBB3 分子产品列表
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- EK1187
- ELISA试剂盒
Human Her3/ErbB3 ELISA Kit检测试剂盒（酶联免疫吸附法）
- ¥2,190.00 – ¥3,650.00
