CD14 靶点信息

CD14 分子靶点信息概述

  • 分子名：CD14, CD14 molecule
  • 基因家族：CD molecules; Scavenger receptors
  • 全称：CD14 antigen

CD14 分子靶点综述

CD14是表达于单核细胞、滤泡间巨噬细胞和树突细胞亚群表面的糖蛋白。CD14与MD-2(LY)和TLR4形成受体复合物，可特异性地对LPS产生应答、传导信号。CD14/MD-2/TLR4受体复合物通过MyD88、TIRAP和TRAF6传导信号，最后激活NF-κB。

CD14, CD14 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD14 分子靶点信息

  • 分子名：CD14, CD14 molecule
  • 别称：
    • cd14 antigen
    • monocyte differentiation antigen CD14
    • myeloid cell-specific leucine-rich glycoprotein
  • 基因序列：NCBI_Gene: 929
  • 蛋白序列：UniProtKB: P08571

人 Human CD14靶点分子功能（预测）

Enables lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in cellular response to bacterial lipopeptide; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interleukin-8 production. Acts upstream of or within cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; and positive regulation of tumor necrosis factor production. Located in Golgi apparatus and membrane raft. Is anchored component of external side of plasma membrane. Part of lipopolysaccharide receptor complex. Implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Biomarker of several diseases, including biliary atresia; cystic fibrosis; lung disease (multiple); perinatal necrotizing enterocolitis; and polycystic kidney disease (multiple).

小鼠 Mouse Cd14 分子靶点信息

小鼠 Mouse Cd14 靶点分子功能（预测）

Predicted to enable lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and toll-like receptor 4 signaling pathway. Located in external side of plasma membrane and membrane raft. Is expressed in several structures, including femur; gallbladder; intestine; reproductive system; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and perinatal necrotizing enterocolitis. Orthologous to human CD14 (CD14 molecule).

大鼠 Rat Cd14 分子靶点信息

  • 分子名：Cd14, CD14 molecule
  • 别称：
    • CD14 antigen
    • monocyte differentiation antigen CD14
    • myeloid cell-specific leucine-rich glycoprotein
  • 基因序列：NCBI_Gene: 60350
  • 蛋白序列：UniProtKB: Q63691

大鼠 Rat Cd14 靶点分子功能（预测）

Predicted to enable lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to magnesium ion; and response to tumor necrosis factor. Located in cell surface; extracellular space; and plasma membrane. Used to study perinatal necrotizing enterocolitis. Biomarker of Hirschsprung's disease; cholestasis; obstructive jaundice; and periodontitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Orthologous to human CD14 (CD14 molecule).

CD14 分子产品列表

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