EK183S

Human VEGF Standard (人血管内皮生长因子 (VEGF) 标准品)

¥280.00

  • 分子靶点:VEGFA, VEGF, VPF
  • 种属:人 (Human)
  • 试剂盒:EK183
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK183S


描述

本产品只包含标准品试剂,如需购买试剂盒请点击下图

商品名

Human VEGF Standard (人血管内皮生长因子 (VEGF) 标准品)

组分

人VEGF冻干标准品V

检测方法

双抗夹心法

样本类型

血清,血浆,细胞培养上清及其他生物学样本

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

检测原理:本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人VEGF抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体,经过孵育,样本中存在的VEGF与固相抗体和检测抗体结合。洗涤去除未结合的物质后,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中VEGF的浓度成正比。加入终止液终止反应,在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human VEGF ELISA Kit (人血管内皮生长因子 (VEGF) ELISA试剂盒) - 标准曲线
标准曲线

分子信息

概述人 VEGFA, VEGF, VPF 靶点信息

VEGFA 分子靶点信息概述

  • 分子名:VEGFA, vascular endothelial growth factor A
  • 基因家族:VEGF family
  • 别名:VEGF-A; VPF
  • 曾用名:VEGF
  • 全称:vascular endothelial growth factor

VEGFA 分子靶点综述

血管内皮生长因子(VEGF)是生长因子的亚家族,具体来说,属于胱氨酸结生长因子中的血小板衍生生长因子(PDGF)家族。它们是重要的信号转导蛋白,参与血管发生(胚胎循环系统从头形成)和血管生成(从已存在的脉管系统生长形成血管)。VEGF可刺激血管发生和血管生成。当血液循环不足时,可参与回复组织供氧系统。VEGF最主要的作用是血管生成。在胚胎形成期,VEGF调控内皮细胞的增殖、迁移和存活,从而调控血管密度和大小,但无法决定血管的类型。在支气管哮喘和糖尿病患者的血清中含有高浓度VEGF。当VEGF过表达时会引起疾病。供血不足时,实体肿瘤的大小受限;而表达VEGF的肿瘤则会不断生长并发生转移。VEGF过表达会导致眼睛视网膜和身体其他部分的血管性疾病。贝伐珠单抗和雷珠单抗可抑制VEGF,并控制或减缓疾病进程。

人 Human VEGFA 分子靶点信息

  • 分子名:VEGFA, vascular endothelial growth factor A
  • 别称:
    • MGC70609
    • MVCD1
    • vascular endothelial growth factor
    • vascular endothelial growth factor A121
    • vascular endothelial growth factor A165
    • vascular permeability factor
    • VEGF
    • VEGF-A
    • VPF
  • 基因序列:NCBI_Gene: 7422
  • 蛋白序列:UniProtKB: P15692

人 Human VEGFA靶点分子功能(预测)

Enables several functions, including fibronectin binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of endothelial cell proliferation; and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including adherens junction; cell surface; and secretory granule. Implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); inflammatory bowel disease (multiple); and respiratory system cancer (multiple).

操作步骤


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引用文献


  1. 细胞培养上清

    Synergistic effects of nanoattapulgite and hydroxyapatite on vascularization and bone formation in a rabbit tibia bone defect model 

  2. 细胞培养上清

    CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis 

  3. Tanshinone Iia Inhibits Β-Catenin/Vegf-Mediated Angiogenesis by Targeting Tgf-Β1 in Normoxic and Hif-1α?in Hypoxic Microenvironments in Human Colorectal Cancer 

  4. B7-H3 Expression in Breast Cancer and Upregulation of Vegf through Gene Silence 

  5. Tanshinone I Inhibits Tumor Angiogenesis by Reducing Stat3 Phosphorylation at Tyr705 and Hypoxia-Induced Hif-1α Accumulation in Both Endothelial and Tumor Cells 

  6. Levels of Erythropoietin and Vascular Endothelial Growth Factor in Surgery-Required Advanced Neovascular Glaucoma Eyes before and after Intravitreal Injection of Bevacizumab 

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