EK117S

Human IL-17A Standard (人白介素17A 标准品)

¥280.00

  • 分子靶点:IL17A, IL17, CTLA8
  • 种属:人 (Human)
  • 试剂盒:EK117
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK117S


描述

本产品只包含标准品试剂,如需购买试剂盒请点击下图

商品名

Human IL-17A Standard (人白介素17A 标准品)

组分

人IL-17A标准品

检测方法

双抗夹心法

样本类型

血清,血浆,细胞培养上清及其他生物学样本

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

检测原理:本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IL-17A抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体,经过孵育,样本中存在的IL-17A与固相抗体和检测抗体结合。洗涤去除未结合的物质后,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中IL-17A的浓度成正比。加入终止液终止反应,在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human IL-17A ELISA Kit (人白介素17A ELISA 试剂盒) - 标准曲线
标准曲线

分子信息

概述人 IL17A, IL17, CTLA8 靶点信息

IL17A 分子靶点信息概述

  • 分子名:IL17A, interleukin 17A
  • 基因家族:Interleukins
  • 别名:IL-17A; IL-17
  • 曾用名:CTLA8; IL17
  • 全称:cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

IL17A 分子靶点综述

IL-17主要由Th17型细胞产生,是目前已发现的30余种白细胞介素中的一员,按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子,可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子,从而导致炎症的产生。

人 Human IL17A 分子靶点信息

  • 分子名:IL17A, interleukin 17A
  • 别称:
    • CTLA-8
    • CTLA8
    • cytotoxic T-lymphocyte-associated antigen 8
    • cytotoxic T-lymphocyte-associated protein 8
    • cytotoxic T-lymphocyte-associated serine esterase 8
    • IL-17
    • IL-17A
    • IL17
    • ILA17
    • interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
    • interleukin-17
    • interleukin-17A
  • 基因序列:NCBI_Gene: 3605
  • 蛋白序列:UniProtKB: Q16552

人 Human IL17A靶点分子功能(预测)

Predicted to enable cytokine activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of osteoclast differentiation. Acts upstream of or within positive regulation of cytokine production and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Biomarker of several diseases, including acne; autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and rhinitis (multiple).

操作步骤


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引用文献


  1. 腹水 血浆

    CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study 

  2. 腹腔上清液

    Alteration of Myeloid-Derived Suppressor Cells, Chronic Inflammatory Cytokines, and Exosomal miRNA Contribute to the Peritoneal Immune Disorder of Patients With Endometriosis 

  3. 血清

    Participation of Increased Circulating MAIT Cells in Lung Cancer: a Pilot Study 

  4. 血浆

    Involvement of Impaired Cd8+ Mucosal-Associated Invariant T Cells and Myeloid-Derived Suppressor Cells in Polycystic Ovary Syndrome 

  5. 细胞培养上清 血清

    Casein Kinase II exacerbates rheumatoid arthritis via promoting Th1 and Th17 cell inflammatory responses 

  6. Low Ratio of Treg to Th17 Cells after 36 Weeks of Telbivudine Therapy Predict Hbeag Seroconversion 

  7. Human Colon Carcinogenesis Is Associated with Increased Interleukin-17-Driven Inflammatory Responses 

  8. Basal Level of Th17 Immune Response Is Not Enhanced in Aplastic Amemia 

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