BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. 仅用于研究。不适用于诊断或治疗。
【别名】Bone Morphogenetic Protein-13, GDF-6, Cartilage-Derived Morphogenetic Protein-2 (CDMP-2)
【描述】BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino-acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. Manufactured using all Animal-Free reagents.
TAFASRHGKR HGKKSRLRCS KKPLHVNFKE
LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL
EPTNHAIIQT LMNSMDPGST PPSCCVPTKL
TPISILYIDA GNNVVYKQYE DMVVESCGCR
【纯度】Greater than 95% by SDS-PAGE gel and HPLC analyses.
【生物活性】Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml.