PeproTech 高品质趋化因子 (Chemokine)

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https://www.liankebio.com/article-information_Newsletter-1668.html

作者:PeproTech 官网 发布日期:2017-04-01 09:00

PeproTech 高品质趋化因子 (Chemokine)趋化因子是一组具有趋化作用的细胞因子,能吸引免疫细胞到免疫应答局部,参与免疫调节和免疫病理反应。它们多为小于100个氨基酸的小分子多肽,根据结构可主要分为4个趋化因子亚家族:Cys-X-Cys(CXC)、Cys-Cys(CC)、Cys(C)、Cys-X3-Cys(CX3C) 亚家族(如下图)。CXC家族成员多数基因定位于第4对染色体,包括IL-8、IP-10(IFN inducible protein-10)、MGSA等,CC家族成员多数基因定位于第17对染色体,包括MIP-1α, β(macrophage inflammatory protein)、 MCP-1(macrophage chemotactic protein)、RANTES (regulated upon activation normal T expressed and secreted)等。C家族只有一个成员Lymphotactin,基因定位于1号染色体。CX3C家族也只有一个成员Fractalkine (neurotactin),基因定位于第16对染色体。

PeproTech Chemokine(趋化因子)产品一览表

系统名称 功能名称(小鼠蛋白) 应答细胞(小鼠蛋白) 已知受体 产品货号
CXC Chemokines
CXCL1 GRO1, GRO-α, MGSA, NAP-3 (KC) PMN CXCR1, CXCR2 300-11/400-10/250-11
CXCL2 GRO2, GRO-β, MIP2-α (MIP-2) PMN CXCR1, CXCR2 300-39/400-11/250-15
CXCL3 GRO3, GRO-γ, MIP2-β (DCIP-1) PMN CXCR2 300-40
CXCL4 PF-4, Oncostatin-A PMN, Mo CXCR3B 300-16/250-39
CXCL5 ENA-78 PMN CXCR2 300-22/300-22B
CXCL6 GCP-2, CKA-3 (LIX) PMN CXCR1, CXCR2 300-41/250-36/250-17
CXCL7 NAP-2, PBP, LDGF, MDGF PMN CXCR1, CXCR2 300-14
CXCL8 IL-8, GCP-1, NAP-1 PMN, Bs CXCR1, CXCR2 200-08/200-08M
CXCL9 MIG actT [Th1], NK CXCR3 300-26/250-18
CXCL10 IP-10 (CRG-2) Mo, actT [Th1], NK CXCR3 300-12/250-16/400-33
CXCL11 I-TAC, IP-9 actT [Th1], NK CXCR3, CXCR7 300-46/250-29
CXCL12 SDF-1, SDF-1α/β, PBSF All cell types CXCR4, CXCR7 300-28A/250-20A/400- 32A/300-28B/250-20B/ 400-32B
CXCL13 BCA-1, BLC B, (Mo) CXCR5 300-47/250-24
CXCL14 BRAK, MIP-2G PMN, mDC (B, Mo) unknown 300-50
CXCL15 (Lungkine) PMN unknown 250-37
CXCL16 SR-PSOX actT CXCR6 300-55/250-28
CXCL17 VEGF co-regulated chemokine 1, DMC Mo, iDC unknown  
C Chemokines
XCL1 Lymphotactin, ATAC, SCM-1 Tr XCR1 300-20
XCL2 SCM-1β Tr XCR1  
CX3C Chemokine
CX3CL1 Fractalkine, Neurotactin, CX3C Mo, actT, NK CX3CR1 300-31/400-26
CC Chemokines
CCL1 I-309 (TCA-3) iDC, actT [Th2], Mo (PMN) CCR8 300-37
CCL2 MCP-1, MCAF, JE Bs, Mo, actT, NK, iDC CCR2, CCR4 300-04/250-10/400-12
CCL3 MIP-1α, LD78α Eo, Mo, actT, NK, iDC (PMN) CCR1,CCR4, CCR5 300-08/250-09/400-15
CCL3L1 LD78β Mo, actT, B CCR1,CCR3, CCR5 300-56
CCL4 MIP-1β , LAG-1 Mo, actT [Th1], NK, iDC CCR5 300-09/250-32/400-09
CCL4L1 LAG-1 gene duplication Mo CCR1, CCR5 300-58
CCL5 RANTES Eo, Bs, Mo, actT, NK, iDC, Tm CCR1, CCR3, CCR4,CCR5 300-06/250-07/400-13
CCL6 (C-10) Mo CCR1 250-06
CCL7 MCP-3 (FIC) Eo, Bs, Mo, actT, NK, iDC CCR1,CCR2, CCR3 300-17/250-08
CCL8 MCP-2 Eo, Bs, Mo, actT, NK, iDC CCR1, CCR2B, CCR3, CCR5 300-15/250-14
CCL9/CCL10 (MIP-1γ, MRP-2) PMN, actT CCR1 250-12
CCL11 Eotaxin Eo, Bs, actT [Th2], iDC CCR3 300-21/250-01
CCL12 (MCP-5) Eo, Bs, Mo, actT, NK, iDC CCR2 250-04
CCL13 MCP-4, CKβ-10 Eo, Bs, Mo, actT, NK, iDC CCR1,CCR2, CCR3 300-24
CCL14 HCC-1 Eo, Mo, T CCR1,CCR3, CCR5 300-38B/300-38
CCL15 MIP-5, MIP-1d, HCC-2, LKN-1 Mo, T CCR1, CCR3 300-43
CCL16 LEC, HCC-4 Mo, actT [Th1] CCR1 300-44
CCL17 TARC (ABCD-2) actT [Th2] CCR4 300-30
CCL18 MIP-4, DC-CK1, PARC, AMAC-1 Tr, iDC unknown 300-34
CCL19 MIP-3β, ELC, Exodus-3, CKβ-11 Tr, actT, mDC CCR7 300-29B/250-27B
CCL20 MIP-3α, LARC, Exodus-1 Tm, B, iDC, PMN CCR6 300-29A/250-27
CCL21 Exodus-2, 6Ckine, SLC Tr, actT, mDC CCR7 300-35/250-13
CCL22 MDC, STCP-1 (ABCD-1) Mo, actT [Th2], NK, iDC CCR4 300-36/300-36A/250-23
CCL23 MIP-3, MPIF-1, CKβ-8 PMN, Mo, Tr CCR1 300-29
CCL24 Eotaxin-2, MPIF-2, CKβ-6 Eo, Bs, actT [Th2], iDc, PMN, Tr CCR3 300-33/250-22
CCL25 TECK Thymocytes, Tr, iDC CCR9 300-45
CCL26 MIP-4α, Eotaxin-3 Eo, Bs, actT [Th2], iDC CCR3 300-48
CCL27 CTACK, ILC, Eskine actT CCR10 300-54/250-26
CCL28 MEC actT, Tr, Eo CCR3, CCR10 300-57/250-30

Tips:

Tm = memory T cells
B = B-cells
actT = activated T cell
Bs = Basophil
Tr = resting T cell
T = T cells
Eo = Eosinophil
NK = Natural Killer cells
Mo = monocyte
PMN = neutrophils
mDC = mature dendritic cells
iDC = immature dendritic cells